For me, TRINTELLIX made a difference.
Individual results may vary.
Side effects and other information you should know about TRINTELLIX
TRINTELLIX has possible side effects. The most common side effects in short-term studies were nausea, constipation, and vomiting. Nausea was usually mild or moderate, and its frequency was dose-related. Nausea generally occurred in the first week, and became less frequent over time. Nausea may continue in some people. Generally, nausea lasted for about 2 weeks.
TRINTELLIX and weight
TRINTELLIX did not have significant impact on weight in short-term studies and during a 6-month phase of a long-term study of patients who responded to TRINTELLIX when compared to patients taking a sugar pill. Some reports of weight gain have been received since product approval.
TRINTELLIX and sexual function
Sexual side effects of antidepressants are known to be under-reported voluntarily by patients, in part because patients may be reluctant to discuss them. To more accurately assess sexual side effects, in addition to voluntary reports, a questionnaire designed to identify sexual side effects was actively used in TRINTELLIX clinical trials to determine how many people actually experienced sexual side effects with TRINTELLIX treatment.
For more information on sexual side effects, please see the Prescribing Information.
Important Safety Information
TRINTELLIX and other antidepressant medicines may cause serious side effects including Serotonin Syndrome, abnormal bleeding, hypomania (manic episodes), visual problems, or low levels of salt in your blood. Please see additional Important Safety Information below.
TRINTELLIX is a prescription medication used to treat Major Depressive Disorder (MDD) in adults that has helped reduce the multiple symptoms of depression (MDD) based on an overall score on a standardized depression rating scale in multiple 6-8 week studies and one maintenance study vs. sugar pill.
TRINTELLIX and other antidepressant medicines may cause serious side effects including Serotonin Syndrome, abnormal bleeding, hypomania (manic episodes), visual problems, or low levels of salt in your blood.Frequently asked questions
Suicidal Thoughts and Actions and Antidepressant Drugs
Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.
Do not take TRINTELLIX if you:
- Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
- Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days
TRINTELLIX may cause serious side effects including:
Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.
Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.
Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.
Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.
Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.
Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.
TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampicin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.
Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.
Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.
Until you know how TRINTELLIX affects you, do not drive, operate heavy machinery or engage in other dangerous activities.
Avoid drinking alcohol while taking TRINTELLIX.
Talk to your healthcare provider.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or
Indication for TRINTELLIX
TRINTELLIX is a prescription medicine used to treat Major Depressive Disorder (MDD) in adults.