David is a mortgage loan officer who also serves as director of operations for his local church. He has been living with depression (MDD) for more than 25 years.
David is a self-described "people person" who enjoys cycling, and is passionate about animal rescue.
David found making connections very difficult
Even though David comes from a large family and is always surrounded by people, he often felt tired, worthless and alone. “People were always around, but I just wanted to avoid them,” he remembers. “I wasn’t sleeping well, and most of the time I couldn’t think straight.” It was during a visit with his counsellor that David first learned about his depression at 26 years old. He felt a great relief to be able to put a name to what he was feeling.
Recently, David’s depression returned with a force he hadn’t experienced before
After his diagnosis, David began treatment with the help of his doctor that got him feeling better. Then while he was on vacation three years ago it all came flooding back. Once he was alone and quiet, he felt his depression more than ever before. No longer able to manage his depression, he began to feel the impact of his symptoms. Even though the experience was difficult, it prompted him to seek help for his depression.
People with depression (MDD) suffer with 5 or more of the following symptoms including either depressed mood or decreased interest or pleasure for 2 or more weeks:
- Depressed mood
- Loss of interest or pleasure
- Diminished ability to think or concentrate, or indecisiveness
- Insomnia or hypersomnia
- Psychomotor agitation or retardation
- Fatigue or loss of energy
- Feelings of worthlessness or excessive guilt
- A significant change in weight or appetite
- Suicidal ideation
David discussed treatment options with his doctor
David realized he couldn’t do it alone any longer. He talked to his doctor about the symptoms he was experiencing: the constant sadness, tiredness, feelings of loneliness, difficulty concentrating, feelings of worthlessness, and loss of interest in things he used to enjoy. That’s when his doctor prescribed TRINTELLIX – a prescription medicine used to treat major depressive disorder in adults.
TRINTELLIX (vortioxetine) is a prescription medicine used to treat Major Depressive Disorder (MDD) in adults.
David has learned over time to connect with his doctor about how he is feeling
Since starting TRINTELLIX, David has noticed an improvement in his depression symptoms. He reports, “…my depression was less of a struggle.” He urges others to reach out for help. He has experienced first hand how important making a connection with his doctor has been. Now he says that he has hope moving forward.
TRINTELLIX helped reduce the multiple symptoms of depression (MDD) based on an overall score on a standardized depression rating scale in multiple 6-8 week studies and one maintenance study vs. sugar pill.
In short-term studies, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later.
Individual results may vary.
Patients featured are on TRINTELLIX at time of interview.
Patients featured are on TRINTELLIX at time of interview.
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Suicidal Thoughts and Actions and Antidepressant Drugs
Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.
Do not take TRINTELLIX if you:
- Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
- Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days
TRINTELLIX may cause serious side effects including:
Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.
Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.
Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.
Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.
Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.
Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.
TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampicin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.
Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.
Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.
Until you know how TRINTELLIX affects you, do not drive, operate heavy machinery or engage in other dangerous activities.
Avoid drinking alcohol while taking TRINTELLIX.
Talk to your healthcare provider.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or
Indication for TRINTELLIX
TRINTELLIX is a prescription medicine used to treat Major Depressive Disorder (MDD) in adults.