90-day savings offer icon

You may pay as little as $10 for either a 30-day or 90-day prescription.*

Learn more

*Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. See Savings Card for Eligibility Requirements and Terms & Conditions.

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*Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. See Savings Card for Eligibility Requirements and Terms & Conditions.

Yeah. That's Better.

You've decided to talk to your doctor about your treatment options. tell it like it is

Patient portrayal.

Individual results may vary.

What is TRINTELLIX?

TRINTELLIX (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

In multiple 6- to 8-week studies and two maintenance studies, TRINTELLIX was shown to help reduce the multiple symptoms of MDD, based on an overall score on a standardized depression rating scale vs. sugar pill.

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DOCTOR DISCUSSION GUIDE

Ready to talk to your doctor? tell it like it is.

This short questionnaire will create a personalized Doctor Discussion Guide for you to download or print. It may be used to start an open and honest conversation about MDD, a type of depression, with your doctor.

Get Started

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SIDE EFFECTS

Side effects. Something to consider.

SIDE EFFECTS

Wondering about side effects, including weight gain?

It’s important to know the possible side effects of a treatment when considering your options.

See side effects

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ANTIDEPRESSANT SEXUAL SIDE EFFECTS

Sexual side effects. Hmmm.

ANTIDEPRESSANT SEXUAL SIDE EFFECTS

Struggling with antidepressant sexual side effects? 

Sexual side effects, such as loss of sexual desire and difficulty becoming aroused or achieving orgasm, can occur with many common antidepressants.

See the data

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PATIENT STORIES

Wait, other people feel this way too?

PATIENT STORIES

Want patient stories?

Want patient stories?

Many patients in the US suffer from MDD. Now, you can get an inside look at the lives of several TRINTELLIX patients, and how they worked with their doctor to manage their MDD.

Individual results may vary.

Hear more stories

Patient portrayal.

tAccess Support Program

Your personalized support and savings program

By enrolling in tAccess (at no cost to you), you can customize your experience through support tools like real patient stories, texts, and emails.

Join tAccess

Plus you may pay as little as $10 for either a 30-day or 90-day prescription.*

*Only commercially insured patients are eligible for savings offer, and offer is subject to maximum savings of $100 per 30-day or $300 per 90-day prescription. See savings card for Eligibility Requirements and Terms & Conditions.

IMPORTANT SAFETY INFORMATION About TRINTELLIX

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Suicidal Thoughts & Actions

TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children under 18. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings. Call your doctor or get emergency help right away if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

  • are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • take a Monoamine Oxidase Inhibitor (MAOI)
  • have stopped taking an MAOI in the last 14 days
  • are being treated with the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

  • about all your medical and other health conditions
  • if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX.
  • if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; fentanyl; lithium; tramadol; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; and diuretics.

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

  • Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
  • Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
  • Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
  • Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
  • Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
  • Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in your blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.

The most common side effects of TRINTELLIX include:

  • nausea
  • constipation
  • vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/antidepressants/

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.