Patient portrayal.

Individual results may vary.

MDD treatment &
TRINTELLIX® (vortioxetine)

TRINTELLIX® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.

  

TRINTELLIX has been proven to effectively treat the overall symptoms of MDD in adults.

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD) that has helped reduce the multiple symptoms of MDD based on an overall score on a standardized depression rating scale in multiple 6-8 week studies and reduced the risk of recurrence in two maintenance studies vs. sugar pill. Individual results may vary. TRINTELLIX has not been shown to be safe and effective for use in children.

The most common side effects of TRINTELLIX in short-term studies were nausea, constipation, and vomiting. Nausea was usually considered to be mild or moderate, and its frequency was dose-related. Nausea generally occurred in the first week and became less frequent over time, usually lasting for about 2 weeks. Nausea may continue in some people. Before starting treatment, talk to your healthcare professional about the risks and benefits of TRINTELLIX. Make sure to discuss all the ways in which you may be dealing with your MDD.

See below for Important Safety Information, including Boxed WARNING for Suicidal Thoughts and Actions.

TRINTELLIX has been studied in over 5,800 adults with MDD between the ages of 18 and 88.

Over 2 million patients have been prescribed TRINTELLIX in the United States.

TRINTELLIX started offering relief from depression symptoms as early as week 2 and lasted long-term.

In short-term studies (6-8 weeks) based on a standardized depression rating scale, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later. This makes it very important to follow your treatment plan, as directed by your healthcare professional. Individual results may vary.

 

MDD patients taking TRINTELLIX showed improvement in processing speed, an important part of cognitive function that may be impaired by MDD.

In clinical studies of patients experiencing a major depressive episode, TRINTELLIX helped improve processing speed, which is how quickly a person can accurately process information. Improvement was evaluated based on a standardized neuropsychological test vs sugar pill. In these studies, the common side effects were headaches, nausea, and diarrhea.

The effect of TRINTELLIX on processing speed may reflect improvement in depression. Studies have not been conducted to compare the effect of TRINTELLIX vs other antidepressants on processing speed.

 

Getting the most from TRINTELLIX

  • Read the information that comes with your prescription, and always take TRINTELLIX exactly as prescribed by your healthcare professional
  • Download the Patient Brochure to help you discuss MDD treatment options and getting started on Trintellix with your doctor
  • Set up a personalized medication reminder now to help you stay on track with your treatment plan as directed by your healthcare professional
  • Learn how eligible, commercially insured patients can get a TRINTELLIX Savings Card for 30- or 90-day prescriptions*

*Only commercially insured patients are eligible for the TRINTELLIX Savings Card. See Savings Card for full Eligibility Requirements and Terms & Conditions.

Frequently Asked Questions

  • Talk to your doctor about the length of treatment with TRINTELLIX. Do not stop taking TRINTELLIX without consulting your doctor.
  • Take TRINTELLIX exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of TRINTELLIX until it is the right dose for you.
  • Do not start or stop any other medicines during treatment with TRINTELLIX without talking to your healthcare provider first.
    • Stopping TRINTELLIX suddenly may cause you to have serious side effects. See the “What are the possible side effects of TRINTELLIX?” FAQ by following the link below.

Selective serotonin re-uptake inhibitors (SSRIs) are a common type of antidepressant used to treat Major Depressive Disorder (MDD) by enhancing the activity of serotonin in specific pathways of the brain.

The mechanism of the antidepressant effect of TRINTELLIX is not fully understood. However, the antidepressant effect of both TRINTELLIX and SSRIs is thought to be related to their enhancement of serotonin activity in the central nervous system. Experts believe that MDD results when certain chemicals in the brain are out of balance. These chemicals, called neurotransmitters, send messages from one brain cell to another by acting at specific receptors. The function and effect of TRINTELLIX is believed to be related to the inhibition of serotonin reuptake. In addition, TRINTELLIX blocks the activities of certain receptors while enhancing that of others. The contribution of these functions to TRINTELLIX's antidepressant effect has not been established.

View all FAQs

Real stories from people taking
TRINTELLIX. Meet the TRINTELLERS.

Click here for Medication Guide

SUPER: When you think of life with Major Depressive Disorder, or MDD, what do you see?

 

VO: When you think of life with Major Depressive Disorder, or MDD, what do you see?

 

VO: People may think they know exactly what MDD looks like.

 

VO: But the truth is that MDD looks different for everyone

 

VO: because everyone experiences it differently.

 

VO: To get a more authentic picture of MDD, we have to look at not just the disorder, but also some people living with it.

 

VO: Because when a patient works with their doctor to find the treatment plan that’s right for them, it may have a noticeable impact on their MDD.

 

VO: That’s what I want other patients to know.

 

SUPER: Who am I?

 

VO: Who am I?

 

SUPER: A real patient with MDD

 

VO: My name is Jesus.

 

SUPER: A real patient with MDD

 

VO: My name is Ruth.

 

SUPER: A real patient with MDD

 

VO: My name is Tatiana.

 

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain

type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

 

VO: Our doctors told us about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

 

SUPER: TRINTELLIX + STORYTELLERS

TRINTELLERS are real MDD patients treated with

TRINTELLIX who are here to share their stories with others.

 

SUPER: TRINTELLIX + STORYTELLERS = TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

 

VO: Now—We’ve become the first TRINTELLERS, a collection of actual TRINTELLIX patients

 

VO: who are telling personal stories of our lives with MDD.

 

VO: Each of us will be recording one second of our lives.

 

VO: everyday, as well as telling you about our recent experiences with MDD,

 

VO: working with our doctors, and our journey with TRINTELLIX.

 

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

 

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people twenty-four and younger.

 

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts or feelings. TRINTELLIX is not for use in children.

 

VO: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

 

SUPER: Do not take with MAOIs.

 

VO: Do not take with MAOIs.

 

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

 

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

 

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

 

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

 

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

 

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

 

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

 

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

 

SUPER: Common side effects include nausea, constipation, and vomiting.

VO: Common side effects include nausea, constipation, and vomiting.

VO: Although we know there isn’t a cure for MDD and that we’ll continue to face challenges, we want to start the conversation and raise awareness for others who may be living with MDD.

 

SUPER: Individual results may vary.

 

VO: Together, we hope to encourage other MDD patients to work with their doctor to find the treatment plan that works for them.

 

SUPER: Medication may not be appropriate for everyone.

 

VO: Thank you and see y’all soon.

 

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to the Medication Guide located at the bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

 

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the Patient and Trademark Office and used under license by Takeda Pharmaceuticals America. Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited. @2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved 1-877-TAKEDA-7 (877-825-3327).

 

US-VOR-0821v2.0 06/24

Real stories from people taking
TRINTELLIX. Meet the TRINTELLERS.

TRINTELLIX + Storytellers = TRINTELLERS.

TRINTELLERS are real patients with MDD treated with TRINTELLIX and who are here to share their stories with others.

These videos were filmed by the TRINTELLERS themselves to help give you an inside look at their lives with MDD.

Hear more stories

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TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

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1-877-TAKEDA-7 (1-877-825-3327).

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