Getting the most from TRINTELLIX
We're here to help. Visit our Resources page to download the Patient Brochure with tips on taking TRINTELLIX and set up a medication reminder.
TRINTELLIX® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.
TRINTELLIX has been proven to effectively treat the overall symptoms of MDD in adults
TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD) that has helped reduce the multiple symptoms of MDD based on an overall score on a standardized depression rating scale in multiple 6-8 week studies, and reduced the risk of recurrence in two maintenance studies vs. sugar pill. Individual results may vary. TRINTELLIX has not been shown to be safe and effective for use in children.
The most common side effects of TRINTELLIX in short-term studies were nausea, constipation, and vomiting. Nausea was usually considered to be mild or moderate, and its frequency was dose-related. Nausea generally occurred in the first week and became less frequent over time, usually lasting for about 2 weeks. Nausea may continue in some people. Before starting treatment, talk to your healthcare professional about the risks and benefits of TRINTELLIX. Make sure to discuss all the ways in which you may be dealing with your MDD.
See below for Important Safety Information, including Boxed WARNING for Suicidal Thoughts and Actions.
TRINTELLIX started offering relief from depression symptoms as early as Week 2 and lasted long term, when taken once a day
In short-term studies (6-8 weeks) based on a standardized depression rating scale, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later. This makes it very important to follow your treatment plan, as directed by your healthcare professional. Individual results may vary.
TRINTELLIX has been studied in over 5,800 adults with MDD between the ages of 18 and 88.
Over 2 million patients have been prescribed TRINTELLIX in the United States.
TRINTELLIX is the only FDA-approved treatment for MDD with data on speed of processing in its Prescribing Information
In clinical studies of patients experiencing a major depressive episode, TRINTELLIX helped improve speed of processing.
Speed of processing is how quickly a person can accurately process information, and is an aspect of cognition that can be affected by depression.
The effect of TRINTELLIX on speed of processing may reflect improvement in depression. Improvement was evaluated vs. sugar pill and based on a standardized neuropsychological test.
Studies have not been conducted to compare the effect of TRINTELLIX vs. other antidepressants on speed of processing.
Getting the most from TRINTELLIX
We're here to help. Visit our Resources page to download the Patient Brochure with tips on taking TRINTELLIX and set up a medication reminder.
Frequently Asked Questions
Speed of processing is how quickly someone can process information, and is an aspect of cognition that can be affected by depression.
Selective serotonin re-uptake inhibitors (SSRIs) are a common type of antidepressant used to treat Major Depressive Disorder (MDD) by enhancing the activity of serotonin in specific pathways of the brain.
The mechanism of the antidepressant effect of TRINTELLIX is not fully understood. However, the antidepressant effect of both TRINTELLIX and SSRIs is thought to be related to their enhancement of serotonin activity in the central nervous system. Experts believe that MDD results when certain chemicals in the brain are out of balance. These chemicals, called neurotransmitters, send messages from one brain cell to another by acting at specific receptors. The function and effect of TRINTELLIX is believed to be related to the inhibition of serotonin reuptake. In addition, TRINTELLIX blocks the activities of certain receptors while enhancing that of others. The contribution of these functions to TRINTELLIX's antidepressant effect has not been established.
- Talk to your doctor about the length of treatment with TRINTELLIX. Do not stop taking TRINTELLIX without consulting your doctor.
- Take TRINTELLIX exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of TRINTELLIX until it is the right dose for you.
- Do not start or stop any other medicines during treatment with TRINTELLIX without talking to your healthcare provider first.
- Stopping TRINTELLIX suddenly may cause you to have serious side effects. See the “What are the possible side effects of TRINTELLIX?” FAQ by following the link below.
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