Major Depressive Disorder Treatment | TRINTELLIX (vortioxetine)

Patient portrayal.Individual results may vary.

MDD treatment &
TRINTELLIX® (vortioxetine)

TRINTELLIX® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.

  

TRINTELLIX has been proven to effectively treat the overall symptoms of MDD in adults.

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD) that has helped reduce the multiple symptoms of MDD based on an overall score on a standardized depression rating scale in multiple 6-8 week studies and two maintenance studies vs. sugar pill. Individual results may vary. TRINTELLIX has not been shown to be safe and effective for use in children.

The most common side effects of TRINTELLIX in short-term studies were nausea, constipation, and vomiting. Nausea was usually considered to be mild or moderate, and its frequency was dose-related. Nausea generally occurred in the first week and became less frequent over time, usually lasting for about 2 weeks. Nausea may continue in some people. Before starting treatment, talk to your healthcare professional about the risks and benefits of TRINTELLIX. Make sure to discuss all the ways in which you may be dealing with your MDD.

See below for Important Safety Information, including Boxed WARNING for Suicidal Thoughts and Actions.

TRINTELLIX has been studied in over 3,300 adults with MDD between the ages of 18 and 88.

Over 1 million patients have been prescribed TRINTELLIX in the United States.

TRINTELLIX started offering relief from depression symptoms as early as week 2 and lasted long-term.

In short-term studies (6-8 weeks) based on a standardized depression rating scale, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later. This makes it very important to follow your treatment plan, as directed by your healthcare professional. Individual results may vary.

 

MDD patients taking TRINTELLIX showed improvement in processing speed, an important part of cognitive function that may be impaired by MDD.

In clinical studies of patients experiencing a major depressive episode, TRINTELLIX helped improve processing speed, which is how quickly a person can accurately process information. Improvement was evaluated based on a standardized neuropsychological test vs sugar pill. In these studies, the common side effects were headaches, nausea, and diarrhea.

The effect of TRINTELLIX on processing speed may reflect improvement in depression. Studies have not been conducted to compare the effect of TRINTELLIX vs other antidepressants on processing speed.

 

Getting the most from TRINTELLIX

  • Read the information that comes with your prescription, and always take TRINTELLIX exactly as prescribed by your healthcare professional
  • Download the Patient Brochure to help you discuss MDD treatment options and getting started on Trintellix with your doctor
  • Set up a personalized medication reminder now to help you stay on track with your treatment plan as directed by your healthcare professional
  • Sign up for the tAccess Support Program for savings and so much more*

*All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients are eligible for the TRINTELLIX Savings Card. See Savings Card for full Eligibility Requirements and Terms & Conditions.
 

Frequently Asked Questions

  • Talk to your doctor about the length of treatment with TRINTELLIX. Do not stop taking TRINTELLIX without consulting your doctor.
  • Take TRINTELLIX exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of TRINTELLIX until it is the right dose for you.
  • Do not start or stop any other medicines during treatment with TRINTELLIX without talking to your healthcare provider first.
    • Stopping TRINTELLIX suddenly may cause you to have serious side effects. See the “What are the possible side effects of TRINTELLIX?” FAQ by following the link below.

Selective serotonin re-uptake inhibitors (SSRIs) are a common type of antidepressant used to treat Major Depressive Disorder (MDD) by enhancing the activity of serotonin in specific pathways of the brain.

The mechanism of the antidepressant effect of TRINTELLIX is not fully understood. However, the antidepressant effect of both TRINTELLIX and SSRIs is thought to be related to their enhancement of serotonin activity in the central nervous system. Experts believe that MDD results when certain chemicals in the brain are out of balance. These chemicals, called neurotransmitters, send messages from one brain cell to another by acting at specific receptors. The function and effect of TRINTELLIX is believed to be related to the inhibition of serotonin reuptake. In addition, TRINTELLIX blocks the activities of certain receptors while enhancing that of others. The contribution of these functions to TRINTELLIX's antidepressant effect has not been established.

   

Real stories from people taking
TRINTELLIX. Meet the TRINTELLERS.

Superscript: When you think of life with Major Depressive Disorder, or MDD, what do you see?

Voice over: When you think of life with Major Depressive Disorder, or MDD, what do you see? People may think they know exactly what MDD looks like. But the truth is that MDD looks different for everyone because everyone experiences it differently. To get a more authentic picture of MDD, we have to look at not just the disorder, but also some people living with it. Because when a patient works with their doctor to find the treatment plan that’s right for them, it may have a noticeable impact on their MDD. That’s what I want other patients to know. 

Superscript: Who am I?

Voice over: Who am I? 

Superscript: A real patient with MDD.

Voice over: My name is Jesus. 

Voice over: My name is Ruth.

Voice over: Hi, I am Tatiana. 

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: Our doctors told us about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD. 

Superscript: TRINTELLIX + STORYTELLERS = TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Voice over: Now-We’ve become the first TRINTELLERS, a collection of actual TRINTELLIX patients who are telling personal stories of our lives with MDD. Each of us will be recording one second of our lives everyday, as well as telling you about our recent experiences with MDD, working with our doctors, and our journey with TRINTELLIX. 

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger. 

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it. 

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX. 

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition. 

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Voice over: Although we know there isn’t a cure for MDD and that we’ll continue to face challenges, we want to start the conversation and raise awareness for others who may be living with MDD.

Superscript: Individual results may vary.

Voice over: Together, we hope to encourage other MDD patients to work with their doctor to find the treatment plan that works for them. 

Superscript: Medication may not be appropriate for everyone.

Voice over: Thank you and see y’all soon. 

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0821v1.0 11/21

Real stories from people taking
TRINTELLIX. Meet the TRINTELLERS.

TRINTELLIX + Storytellers = TRINTELLERS.

TRINTELLERS are real patients with MDD treated with TRINTELLIX and who are here to share their stories with others.

These videos were filmed by the TRINTELLERS themselves to help give you an inside look at their lives with MDD. 

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IMPORTANT SAFETY INFORMATION about TRINTELLIX

Suicidal Thoughts & Actions

TRINTELLIX and other antidepressants increase the risk of suicidal thoughts and actions in people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. Call your doctor or get emergency help right away to report any of these, or if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

  • are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • are taking, or have stopped taking within the last 14 days, a medicine called a Monoamine Oxidase Inhibitor (MAOI), including the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

  • about all your medical and other health conditions
  • if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX
  • if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; lithium; tramadol, fentanyl, meperidine, methadone, or other opioids; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; diuretics; medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs); or medicines used to treat seizures or convulsions.

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

  • Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart-beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
  • Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
  • Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
  • Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
  • Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
  • Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in their blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
  • Sexual problems: Taking TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your doctor if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.

The most common side effects of TRINTELLIX include:

  • nausea
  • constipation
  • vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1‑800‑FDA‑1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.

 

There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at 

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.