Doctor Discussion Guide | TRINTELLIX (vortioxetine)

Patient portrayal.Individual results may vary.

Doctor discussion guide

TRINTELLIX® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.

Have a real talk with your doctor

Living with Major Depressive Disorder (MDD) can be exhausting. If you feel you could be doing better with your MDD, consider talking with your doctor about your concerns. At your appointment, your doctor may suggest TRINTELLIX as a treatment option for you to think about. We’ve created this 4-minute questionnaire as a tool to help guide your discussion with your doctor, since it can be hard to remember everything you want to say during the appointment.


Have you ever been diagnosed with MDD by a doctor?

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Skip this step if you’d like to get the doctor discussion guide without providing personal information. You will still be able to download your completed guide as a PDF.


If you haven't been diagnosed with MDD, we recommend you fill out the symptom checklist.

Depression is more than just sadness. There are multiple symptoms of MDD. You can use our symptom checklist to evaluate how you're feeling.




Download a blank discussion guide to fill out by hand.


Are you ready to have a real talk with your doctor?

How would you describe the way you're currently feeling?

You deserve to get the support you need. Give your doctor an overall sense of how things are going for you.


Remember: This discussion guide is not a diagnostic tool. Only your doctor can diagnose you with MDD.



Reflect on the past 8 weeks. Which symptoms of MDD have you experienced or are currently experiencing?

Depression is more than just sadness. MDD can include emotional, physical, and cognitive symptoms. TRINTELLIX has been proven to effectively treat the overall symptoms of MDD in adults.

Select all that apply and share the information with your doctor. At your appointment, you should also let your doctor know if any symptoms have gotten worse or more bothersome.



Remember: This discussion guide is not a diagnostic tool. Only your doctor can diagnose you with MDD.



Have you experienced any of the following common antidepressant side effects before?

All medications come with a risk of side effects. Sometimes side effects can go away on their own, but sometimes they may need more work to manage.

Select all that apply–you are your own best advocate. It’s important for your doctor to know about any side effects you’ve experienced so that they can work to address your overall MDD symptoms while minimizing side effects.


Have other concerns? It's important to share them with your doctor. When you download your completed questionnaire, it will have a space for you to make your own notes, so be sure to use it in order to help you have an open conversation.


Remember: This discussion guide is not a diagnostic tool. Only your doctor can diagnose you with MDD.



Once you click “Submit”, your responses will be placed into a guide that you can bring to your next appointment.



Now you're ready to have a real talk with your doctor

Your next step is to schedule an appointment and use your completed doctor discussion guide to talk about your concerns. Talking with your doctor about what you’re really going through is the first step to finding a treatment that brings you relief.


How would you like to receive your doctor discussion guide?

There are two ways you can receive your personalized discussion guide. You can have it emailed to you or you can download it directly to your computer.

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Keep an eye on your inbox, your personalized doctor discussion guide should arrive soon. Once you get it, you can download it and add your own notes in the space provided to help simplify your conversation with your doctor.

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Be sure to add your own notes in the space provided to help you remember all that you want to discuss with your doctor.

Hear from real people with MDD

Before you go, get an inside look at the lives of real people with MDD who are taking TRINTELLIX.

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Note: This discussion guide is not a diagnostic tool. Having some of the symptoms that are listed in the guide does not necessarily mean you have Major Depressive Disorder (MDD). Only a doctor or other healthcare professional can diagnose MDD. Please contact your healthcare provider immediately if you are feeling suicidal, or contact the by calling or texting 988.



Suicidal Thoughts & Actions

TRINTELLIX and other antidepressants increase the risk of suicidal thoughts and actions in people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. Call your doctor or get emergency help right away to report any of these, or if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

  • are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • are taking, or have stopped taking within the last 14 days, a medicine called a Monoamine Oxidase Inhibitor (MAOI), including the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

  • about all your medical and other health conditions
  • if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX
  • if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; lithium; tramadol, fentanyl, meperidine, methadone, or other opioids; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; diuretics; medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs); or medicines used to treat seizures or convulsions.

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

  • Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart-beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
  • Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
  • Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
  • Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
  • Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
  • Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in their blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
  • Sexual problems: Taking TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your doctor if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.

The most common side effects of TRINTELLIX include:

  • nausea
  • constipation
  • vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1‑800‑FDA‑1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.


There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at 

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.