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So, this works how?

Patient portrayal. Individual results may vary.


So you’re wondering how TRINTELLIX works?

Experts believe that Major Depressive Disorder (MDD) results when certain chemicals in the brain are out of balance. These chemicals, called neurotransmitters, send messages from one brain cell to another by acting at specific receptors. 

Although it's not fully understood, TRINTELLIX is thought to work by enhancing the activity of a neurotransmitter called serotonin in the brain by blocking serotonin reuptake. 

It also has activities on some of the receptors for this brain chemical. The link between this information and therapeutic benefit is not known.



TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

When you think of life with Major Depressive Disorder, or MDD, what do you see? People may think they know exactly what MDD looks like. But the truth is that MDD looks different for everyone, because everyone experiences it differently. To get a more authentic picture of MDD, we have to look at not just the disorder, but also some people living with it. Because when a patient works with their doctor to find the treatment plan that’s right for them, it may have a noticeable impact on their MDD. That’s what I want other patients to know. Who am I? My name is Jesus. My name is Ruth. Hi, I am Tatiana. Our doctors told us about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD. Now, we’ve become the first TRINTELLERS, a collection of actual TRINTELLIX patients who are telling personal stories of our lives with MDD. Each of us will be recording one second of our lives every day, as well as telling you about our recent experiences with MDD, working with our doctors, and our journey with TRINTELLIX.

Antidepressants, like TRINTELLIX, may increase suicidal thoughts and behaviors in children, teens, and young adults. Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior, or thoughts of suicide while taking it. Do not take it if you take MAOIs, are allergic to vortioxetine or any other ingredients in TRINTELLIX. Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition. Increased risk of bleeding and bruising may occur, especially if taken with NSAID pain relievers, aspirin, or blood thinners. Manic episodes can occur. Call your doctor if you have any unusual changes in mood, behavior, or thoughts. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels. Common side effects include nausea, constipation, and vomiting.

Although we know there isn’t a cure for MDD and that we’ll continue to face challenges, we want to start the conversation and raise awareness for others who may be living with MDD. Together, we hope to encourage other MDD patients to work with their doctor to find the treatment plan that works for them. Thank you and see y’all soon.

Get to know real TRINTELLIX patients as they share their stories of life with MDD. From their journey to diagnosis, to how they worked with their doctor to manage their MDD, this is your chance to get an inside look at their lives.

Hear more stories

Important Safety Information About TRINTELLIX


Suicidal Thoughts and Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.

Do not take TRINTELLIX if you:

  • Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days

TRINTELLIX may cause serious side effects including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.

Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.

Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.

TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.

Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.

Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.

Talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.


TRINTELLIX is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD) in adults.

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.