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So, this works how?

Patient portrayal. Individual results may vary.


So you’re wondering how TRINTELLIX works?

Experts believe that Major Depressive Disorder (MDD) results when certain chemicals in the brain are out of balance. These chemicals, called neurotransmitters, send messages from one brain cell to another by acting at specific receptors. 

Although it's not fully understood, TRINTELLIX is thought to work by enhancing the activity of a neurotransmitter called serotonin in the brain by blocking serotonin reuptake. 

It also has activities on some of the receptors for this brain chemical. The link between this information and therapeutic benefit is not known.



TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

When you think of life with Major Depressive Disorder, or MDD, what do you see? People may think they know exactly what MDD looks like. But the truth is that MDD looks different for everyone, because everyone experiences it differently. To get a more authentic picture of MDD, we have to look at not just the disorder, but also some people living with it. Because when a patient works with their doctor to find the treatment plan that’s right for them, it may have a noticeable impact on their MDD. That’s what I want other patients to know. Who am I? My name is Jesus. My name is Ruth. Hi, I am Tatiana. Our doctors told us about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD. Now, we’ve become the first TRINTELLERS, a collection of actual TRINTELLIX patients who are telling personal stories of our lives with MDD. Each of us will be recording one second of our lives every day, as well as telling you about our recent experiences with MDD, working with our doctors, and our journey with TRINTELLIX.

Antidepressants, like TRINTELLIX, may increase suicidal thoughts and behaviors in children, teens, and young adults. Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior, or thoughts of suicide while taking it. Do not take it if you take MAOIs, are allergic to vortioxetine or any other ingredients in TRINTELLIX. Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition. Increased risk of bleeding and bruising may occur, especially if taken with NSAID pain relievers, aspirin, or blood thinners. Manic episodes can occur. Call your doctor if you have any unusual changes in mood, behavior, or thoughts. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels. Common side effects include nausea, constipation, and vomiting.

Although we know there isn’t a cure for MDD and that we’ll continue to face challenges, we want to start the conversation and raise awareness for others who may be living with MDD. Together, we hope to encourage other MDD patients to work with their doctor to find the treatment plan that works for them. Thank you and see y’all soon.

Get to know real TRINTELLIX patients as they share their stories of life with MDD. From their journey to diagnosis, to how they worked with their doctor to manage their MDD, this is your chance to get an inside look at their lives.

Hear more stories



Suicidal Thoughts & Actions

TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children under 18. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings. Call your doctor or get emergency help right away if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

  • are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • take a Monoamine Oxidase Inhibitor (MAOI)
  • have stopped taking an MAOI in the last 14 days
  • are being treated with the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

  • about all your medical and other health conditions
  • if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX.
  • if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; fentanyl; lithium; tramadol; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; and diuretics.

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

  • Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
  • Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
  • Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
  • Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
  • Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
  • Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in your blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.

The most common side effects of TRINTELLIX include:

  • nausea
  • constipation
  • vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.