SUPER: Marisol’s Story: Overcoming stigma and finding treatment

VO (Marisol): My name is Marisol.

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): I grew up in the Bronx in a traditional Puerto Rican family within a large Hispanic community.

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): My parents raised me in the same culture as their parents: we got tough love and strictness,...

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): ...women took on more traditional gender roles, and there was never any discussion around mental health.

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): When I was young and voiced concern about my mental health, I was told, “You don’t know what you’re talking about,” or, “¿Qué sabes tú?”

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): I was taught mental health wasn’t a real concern. It was always pushed to the side, so I did the same,...

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): ...which stopped me from addressing my own mental health for a long time...

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): I needlessly struggled with a lot of shame and guilt. But I didn’t know any better.

SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): Then, one day, I reached a tipping point and wound up in the hospital,...

 SUPER: Marisol is a real patient with Major Depressive Disorder (MDD). Marisol is a paid speaker for Takeda and Lundbeck.

VO (Marisol): ...where I was later diagnosed with Major Depressive Disorder, or MDD, at age 48.

SUPER: Marisol is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, difficulty concentrating, low energy, and excessive guilt. These are not all the symptoms of MDD.

VO (Marisol): Surprisingly, the diagnosis was the best thing that could’ve happened to me. I had likely been depressed for years. I was just tolerating life.

SUPER: Marisol is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, difficulty concentrating, low energy, and excessive guilt. These are not all the symptoms of MDD.

VO (Marisol): But it didn’t have to be that way. I just needed some help.

VO (Marisol): After my time at the hospital, I worked with a mental health counselor and then a psychiatrist to figure out my next steps.

VO (Marisol): My psychiatrist’s suggestion was to try TRINTELLIX, a prescription medicine for adults with depression.

SUPER: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO (Marisol): It’s been proven to effectively treat the overall symptoms of depression.

SUPER: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

VO (MRS): TRINTELLIX increases the risk of suicidal thoughts and actions in people twenty-four and younger.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO (MRS): Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood,...

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO (MRS): ...behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO (MRS): Do not take with MAOIs.

SUPER: Do not take with MAOIs.

VO (MRS): Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO (MRS): Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

 SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO (MRS): Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur. Suddenly stopping TRINTELLIX may cause serious side effects.

VO (MRS): Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur. Suddenly stopping TRINTELLIX may cause serious side effects.

VO (MRS): Common side effects include nausea, constipation, and vomiting.

 SUPER: Common side effects include nausea, constipation, and vomiting.

VO (Marisol): I was looking for the right treatment for me, so I gave it a try, and within a month, I started seeing a difference.

VO (Marisol): Looking back, I can see how cultural beliefs and stigmas surrounding mental health stopped me from getting the help I needed even sooner.

VO (Marisol): I didn’t realize how much I’d been missing out on all these years.

VO (Marisol): Whether we know it or not, what our family and friends believe can impact how we understand ourselves.

VO (Marisol): To anyone living with the shame from the negative stigmas surrounding mental health: You and your mental health are important.

VO (Marisol): Finding your treatment plan doesn’t have to take a long time.

VO (Marisol): If you think something is wrong: don’t wait, take the first step and talk to your doctor.

VO (Marisol): I hope my story can help you find the support you need.

VO (Marisol): Ask your doctor about MDD, your treatment options, and if TRINTELLIX could be right for you.

SUPER: Ask your doctor about MDD, your treatment options, and if TRINTELLIX could be right for you. Individual results may vary. Only a doctor can diagnose and treat MDD.

VO (Marisol): Hear more from the TRINTELLERS: real people living with MDD.

SUPER: TRINTELLIX logo

SUPER: +

SUPER: Storytellers

SUPER: =

SUPER: Trintellers

SUPER: Trintellers (TRINTELLIX + Storytellers) TRINTELLERS are real patients with MDD treated with TRINTELLIX who are here to share their stories with others.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to the Medication Guide located at the bottom of this video player and talk to your doctor. You are encouraged to report the negative side effects of prescription drugs to the FDA. Visit www.fda.gov/ medwatch, or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited. ©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).

US-VOR-1428v1.0 07/24

SUPER: Jesus, a real patient with MDD. Jesus is a paid speaker for Takeda and Lundbeck.

VO: Before I found out I had depression, I was dealing with my symptoms on my own, not knowing what was really going on.

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I was feeling sad, lost interest in things I used to like, and noticed a change in my weight.

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I was dealing with these and other symptoms and it really started to get to me.

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: The people closest to me noticed that I was struggling, but it felt like no one truly understood what I was going through.

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: Living with depression can be really hard, and I remember realizing that I couldn’t continue like this on my own. I needed to do something about it.

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: That’s what really convinced me to talk to a doctor, but it took time for me to find the right one who I felt I could trust.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO: And when I finally did, my doctor told me about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder.

VO: He told me that TRINTELLIX worked and that it could be a good treatment for me to try.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people twenty-four and younger.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Do not take with MAOIs.

VO: Do not take with MAOIs.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO: Common side effects include nausea, constipation, and vomiting.

SUPER: Medication may not be appropriate for everyone.

VO: Looking back, I wish I had figured this out with my doctor earlier.

SUPER: Individual results may vary.

VO: There’s good days and there’s bad days, it’s never perfect.

SUPER: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

VO: But having a treatment that has given some relief from my MDD has been a real change.

VO: Overall, this journey has been a big shift, and I‘m looking forward to seeing what comes next.

SUPER: Hear from more real patients living with MDD who are taking TRINTELLIX (vortioxetine).

SUPER: Ruth

SUPER: Tatiana

SUPER: and talk to your doctor about finding a treatment plan that’s right for you. Medication may not be appropriate for everyone.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited. ©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0740v2.0 06/24

SUPER: What can life with MDD* look like? *Major Depressive Disorder

SUPER: Well, that depends.

SUPER: For Jesus, it looks like this:

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD. Jesus, a real patient with MDD. Jesus is a paid speaker for Takeda and Lundbeck.

VO: My name is Jesus.

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I'm a dog dad,

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: a friend,

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: and sometimes I'm an amateur karaoke singer.

SUPER: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I also have depression, which has many symptoms and it can darken my days.

VO: My life motto is to try and find the good things even in bad situations.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO: After going to my doctor for help, they prescribed TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

SUPER: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

VO: Since then, I’ve felt relief from my overall MDD symptoms.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Do not take with MAOIs.

VO: Do not take with MAOIs.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO: Common side effects include nausea, constipation, and vomiting.

VO: I’m sharing my story because I want to help connect with other people who have depression

SUPER: Talk to your doctor to find a treatment plan that’s right for you. Medication may not be appropriate for everyone.

VO: to show them that they’re not alone and that their condition does not define them. So talk to your doctor to find a treatment plan that’s right for you.

SUPER: Hear more patient stories.

SUPER: TRINTELLIX + STORYTELLERS= TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

SUPER: TRINTELLIX + STORYTELLERS= TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0745v2.0 06/24

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: When I think about depression, I think about all the people who are probably like me. People who are struggling, and just want to find a way to feel better.

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD. Ruth, a real patient with MDD. Ruth is a paid speaker for Takeda and Lundbeck.

VO: Because of my depression I can experience feelings of sadness.

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I find myself uninterested in the things I usually care about, and I often feel tired.

VO: I think having support is important.

VO: My sister was always there for me. She would listen to me talk about the difficulties I faced and even helped me look into options to talk to my doctor about.

VO: I started working with my doctor to try to find a treatment plan that worked for me, but it didn’t happen in a day. Eventually, we found one, but it took a little while to get there.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO: One day my doctor and I discussed TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, and decided it could be a good fit for me. 

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people twenty-four and younger.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children

SUPER: Do not take with MAOIs.

VO: Do not take with MAOIs.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO: Common side effects include nausea, constipation, and vomiting.

SUPER: Individual results may vary.

VO: Sure, some days are still harder than others, but having a plan in place and working with my doctor has helped manage my MDD.

VO: I know that if I continue being open with the people in my life who are there to support me, and stick to my plan, I’ll be able to continue on this journey

VO: Even though I know there will be challenges, I’m looking forward to seeing what’s next.

SUPER: Hear from more real patients living with MDD who are taking TRINTELLIX (vortioxetine).

SUPER: Jesus

SUPER: Tatiana

SUPER: and talk to your doctor about finding a treatment plan that’s right for you. Medication may not be appropriate for everyone.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA . Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited. ©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0731v2.0 06/24

SUPER: What can life with MDD* look like? *Major Depressive Disorder

SUPER: Well, that depends.

SUPER: For Ruth, it looks like this:

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD. Ruth, a real patient with MDD. Ruth is a paid speaker for Takeda and Lundbeck.

VO: My name is Ruth.

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I’m an avid reader,

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I love to travel

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: and work on puzzles.

SUPER: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I also have depression, and it can really get in the way.

VO: A life with depression comes with challenges, and some days are harder than others. But my life motto has always been to embrace gratitude and try my best every day.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO: My doctor prescribed TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people twenty-four and younger.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Do not take with MAOIs.

VO: Do not take with MAOIs.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO: Common side effects include nausea, constipation, and vomiting.

SUPER: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

VO: Ever since taking TRINTELLIX, I’ve noticed an improvement in my overall MDD symptoms.

VO: I’m sharing my story because

VO: I want to encourage others to not give up, and to seek whatever help they may need.

SUPER: Talk to your doctor to find a treatment plan that’s right for you. Medication may not be appropriate for everyone.

VO: So talk to your doctor to find a treatment plan that’s right for you.

SUPER: Hear more patient stories.

SUPER: TRINTELLIX + STORYTELLERS = TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

SUPER: TRINTELLIX + STORYTELLERS = TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited. ©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0736v2.0 06/24

SUPER: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD. Tatiana, a real patient with MDD. Tatiana is a paid speaker for Takeda and Lundbeck.

VO: My road to find the right treatment plan for my depression wasn’t easy.

VO: It’s hard to look back on, but I had honestly forgotten what it felt like to not be sad all the time.

SUPER: These are not all of the MDD symptoms you may experience.

VO: There are lots of symptoms that come with my type of depression, but I personally dealt with feelings of sadness, a loss of interest in things that I like, and it was hard for me to concentrate.

SUPER: These are not all of the MDD symptoms you may experience.

VO: I realized that I couldn’t handle these and other MDD symptoms on my own.

VO: I had moved a lot, so I was changing doctors all the time, which made it harder to find the treatment that was right for me.

VO: But I knew I couldn’t give up.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO: That’s when I began working with my current doctor, who prescribed me TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

SUPER: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

VO: Now that I’ve been on TRINTELLIX, I’ve seen relief from my overall MDD symptoms.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Do not take with MAOIs.

VO: Do not take with MAOIs

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO: Common side effects include nausea, constipation, and vomiting.

VO: It’s not easy, but I want people to know that there may be a light at the end of the tunnel.

VO: You’ve gotta be open about how you’re feeling, gotta speak up to your doctor, continue working together to find the right plan for you.

VO: I’m going to continue on this journey, because it’s worth it to me.

SUPER: Hear from more real patients living with MDD who are taking TRINTELLIX (vortioxetine).

SUPER: Jesus

SUPER: Ruth

SUPER: and talk to your doctor about finding a treatment plan that’s right for you. Medication may not be appropriate for everyone

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/ S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited. ©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved.1-877-TAKEDA-7 (877-825-3327).

US-VOR-0730v2.0 06/24

SUPER: What can life with MDD* look like? *Major Depressive Disorder

SUPER: Well, that depends.

SUPER: For Tatiana, it looks like this:

SUPER: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD. Tatiana, a real patient with MDD. Tatiana is a paid speaker for Takeda and Lundbeck.

VO: My name is Tatiana.

SUPER: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: When I’m not traveling, I like to play video games,

SUPER: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: watch TV,

SUPER: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: and hang out with my cat.

SUPER: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD.

VO: I also have depression, which can make me feel negative about myself and hopeless.

VO: I always remind myself “it’s okay to not be okay”. But that doesn’t mean you have to face challenges alone.

SUPER: What is TRINTELLIX?

TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO: After going to my doctor for help, they prescribed me TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people twenty-four and younger.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Do not take with MAOIs.

VO: Do not take with MAOIs.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO: Common side effects include nausea, constipation, and vomiting.

SUPER: Individual results may vary.

VO: Since then, I feel like I’ve learned how to better manage my MDD, and finding the right treatment for me was a big part of that.

VO: I’m sharing my story because I want others to know what having MDD may look like,

SUPER: Medication may not be appropriate for everyone. Individual results may vary.

VO: and encourage them to reach out to a doctor the way that I did.

SUPER: Talk to your doctor to find a treatment plan that’s right for you. Medication may not be appropriate for everyone.

VO: You are not alone. Talk to your doctor to find a treatment plan that’s right for you.

SUPER: Hear more patient stories.

SUPER: TRINTELLIX + STORYTELLERS = TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

SUPER: TRINTELLIX + STORYTELLERS = TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0748v2.0 06/24

VO (DeAnna): For a long time I tried dealing with depression on my own. But eventually, it became clear…

SUPER: on my own

VO (DeAnna): ...that I was keeping too much inside, and my friends and family could tell that I was struggling.

VO (DeAnna): Once I shared how I was feeling with the people I love, getting the help I needed...

SUPER: shared how I was feeling

VO (DeAnna): ...felt much more manageable…

VO (DeAnna): ...and it took some time, but I found a doctor that I was able to build a great relationship with.

VO (DeAnna): We’ve worked together for years now, and in that time my treatment plan has evolved.

VO (DeAnna): I was frustrated at first, but she helped me understand that progress…

VO (DeAnna): ...can be slow, and not to get discouraged. We would try different...

VO (DeAnna): ...ways of coping with MDD,...

VO (DeAnna): ...and each time we met I would tell her what’s working and what’s not,...

VO (DeAnna): ...so we could keep moving in the right direction.

SUPER: right direction

VO (DeAnna): One day we were checking in, and I was telling her how I still wasn’t feeling like we had gotten it right.

VO (DeAnna): She agreed and suggested I try TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

SUPER: What is TRINTELLIX?

TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO (MRS): Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Do not take with MAOIs.

SUPER: Do not take with MAOIs.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Common side effects include nausea, constipation, and vomiting.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO (DeAnna): I hope that hearing my story helps encourage people…

VO (DeAnna): ...at all stages of their MDD journey, to always…

VO (DeAnna): ...be honest with their doctor, and keep that line of communication open.

VO (DeAnna): It may take some time, and there will be twists and turns…

VO (DeAnna): ...but you deserve to find the treatment plan that works best for you.

SUPER: works best for you

VO (DeAnna): Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you.

SUPER: Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you. Individual results may vary. Only a doctor can diagnose and treat MDD.

SUPER: Trintellix logo.

SUPER: +

SUPER: Storytellers

SUPER: =

SUPER: Trintellers (TRINTELLIX + Storytellers)

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to the Medication Guide located at the bottom of this video player and talk to your doctor. You are encouraged to report the negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).

US-VOR-0985v2.0 06/24

SUPER: How DeAnna Saved on Medication

VO (DeAnna): When considering medications, I always ask things like: will it work for me? What are the side effects? And, as a single mom: can I afford it?

SUPER: DeAnna is a real patient with Major Depressive Disorder (MDD). DeAnna is a paid speaker for Takeda and Lundbeck.

VO (DeAnna): It was when I was at my darkest, lowest point, that I knew I needed to take action.

SUPER: DeAnna is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, difficulty concentrating, low energy, and excessive guilt. These are not all the symptoms of MDD.

VO (DeAnna): So, I talked to my doctor and she recommended TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO (DeAnna): TRINTELLIX was shown to help reduce the overall symptoms of MDD. And there were some nice surprises ahead—including the TRINTELLIX Savings Card.

SUPER: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

VO: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

SUPER: TRINTELLIX increases the risk of suicidal thoughts and actions in people 24 and younger.

VO: Call a doctor right away if you have these, or new or worsening depression,

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

SUPER: Call a doctor right away if you have these, or new or worsening depression, or new or sudden changes in mood, behavior, thoughts, or feelings. TRINTELLIX is not for use in children.

VO: Do not take with MAOIs.

SUPER: Do not take with MAOIs.

VO: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

SUPER: Tell your doctor about all medicines you take, to avoid a life-threatening condition.

VO: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

SUPER: Increased risk of bleeding may occur, especially if taken with aspirin, NSAID pain relievers, or blood thinners.

VO: Manic episodes, eye problems, low sodium levels,

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: and sexual problems can occur.

SUPER: Manic episodes, eye problems, low sodium levels, and sexual problems can occur.

VO: Suddenly stopping TRINTELLIX may cause serious side effects.

SUPER: Suddenly stopping TRINTELLIX may cause serious side effects.

VO: Common side effects include nausea, constipation, and vomiting.

SUPER: Common side effects include nausea, constipation, and vomiting.

VO (DeAnna): After talking with my doctor, I wanted to give TRINTELLIX a try, but learned that I would have had a high co-pay with my insurance. I almost walked away.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO (DeAnna): But before giving up, I called my doctor’s office again, and they told me about the TRINTELLIX Savings Card. Enrollment was easy from sign up to pick up. You can even do it yourself: simply check your eligibility on the TRINTELLIX website and activate your Savings Card.

SUPER: Restrictions apply. See the TRINTELLIX Savings Card for Eligibility Requirements and Terms & Conditions. Commercially insured patients only.

VO (DeAnna): Getting the Savings Card was a win for me. Depending on your eligibility, you can get either a 30- or a 90-day prescription for as little as $10.

SUPER: Restrictions apply. See the TRINTELLIX Savings Card for Eligibility Requirements and Terms & Conditions. Commercially insured patients only.

VO (DeAnna): I’m glad I talked to my doctor because, with TRINTELLIX, I feel I now have more control over my MDD.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO (DeAnna): It was small steps at first, but eventually...

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO (DeAnna): ...TRINTELLIX helped improve my MDD.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO (DeAnna): I’m thankful for TRINTELLIX and the Savings Card. Without them, I wouldn’t be where I am today.

SUPER: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children. By prescription only.

VO (DeAnna): Ask your doctor about TRINTELLIX and the Savings Card to see if it could be right for you.

SUPER: Restrictions apply. See the TRINTELLIX Savings Card for Eligibility Requirements and Terms & Conditions. Commercially insured patients only.

VO (DeAnna): Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you.

SUPER: Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you. Individual results may vary. Only a doctor can diagnose and treat MDD.

SUPER: TRINTELLIX logo.

SUPER: +

SUPER: Storytellers

SUPER: =

SUPER: Trintellers

SUPER: Trintellers (TRINTELLIX + Storytellers)

TRINTELLERS are real patients with MDD treated with TRINTELLIX who are here to share their stories with others.

SUPER: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to the Medication Guide located at the bottom of this video player and talk to your doctor. You are encouraged to report the negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

SUPER: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2024 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).

US-VOR-1327v2.0 07/24