Patient Ambassadors Stories & Reviews | TRINTELLIX (vortioxetine)

TRINTELLIX® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.

Real stories from people taking TRINTELLIX. Meet the TRINTELLERS.

Superscript: When you think of life with Major Depressive Disorder, or MDD, what do you see?

Voice over: When you think of life with Major Depressive Disorder, or MDD, what do you see? People may think they know exactly what MDD looks like. But the truth is that MDD looks different for everyone because everyone experiences it differently. To get a more authentic picture of MDD, we have to look at not just the disorder, but also some people living with it. Because when a patient works with their doctor to find the treatment plan that’s right for them, it may have a noticeable impact on their MDD. That’s what I want other patients to know. 

Superscript: Who am I?

Voice over: Who am I? 

Superscript: A real patient with MDD.

Voice over: My name is Jesus. 

Voice over: My name is Ruth.

Voice over: Hi, I am Tatiana. 

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: Our doctors told us about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD. 

Superscript: TRINTELLIX + STORYTELLERS = TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Voice over: Now-We’ve become the first TRINTELLERS, a collection of actual TRINTELLIX patients who are telling personal stories of our lives with MDD. Each of us will be recording one second of our lives everyday, as well as telling you about our recent experiences with MDD, working with our doctors, and our journey with TRINTELLIX. 

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger. 

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it. 

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX. 

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition. 

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Voice over: Although we know there isn’t a cure for MDD and that we’ll continue to face challenges, we want to start the conversation and raise awareness for others who may be living with MDD.

Superscript: Individual results may vary.

Voice over: Together, we hope to encourage other MDD patients to work with their doctor to find the treatment plan that works for them. 

Superscript: Medication may not be appropriate for everyone.

Voice over: Thank you and see y’all soon. 

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0821v1.0 11/21

Real stories from people taking TRINTELLIX. Meet the TRINTELLERS.

TRINTELLIX + Storytellers = TRINTELLERS.

TRINTELLERS are real patients with MDD treated with TRINTELLIX and who are here to share their stories with others.

These videos were filmed by the TRINTELLERS themselves to help give you an inside look at their lives with MDD. 

New TRINTELLERS discuss the impact of their MDD symptoms.

Superscript: When you think of life with Major Depressive Disorder or MDD, what comes to mind?

Voice over: When you think of life with Major Depressive Disorder or MDD, what comes to mind?

Superscript: These videos were filmed by real people living with MDD.

Voice over: It’s a struggle dealing with the multiple symptoms of MDD and how they show up in your life. You work closely with your doctor to find ways of coping, but it’s complicated, and finding the right treatment plan for you can take time. But it’s important never to give up,

Superscript: You’re not alone.

Voice over: because you’re not alone.

Superscript: Who are we?

Voice over: Who are we?

Superscript: I am April. A person living with MDD. This is one patient’s personal experience.

Voice over: I am April.

Superscript: Christi. A person living with MDD. This is one patient’s personal experience.

Voice over: Christi.

Superscript: Marisol. A person living with MDD. This is one patient’s personal experience.

Voice over: Marisol.

Superscript: I am DeAnna. A person living with MDD. This is one patient’s personal experience.

Voice over: I am DeAnna.

Voice over: I’m a single working mother of three boys. And I dedicate a lot of my time to them. Though, sometimes, I forget the importance of taking care of myself. Even though I was doing these things to help with my depression, I still felt like it was me against all these MDD symptoms.

Superscript: These are not all the symptoms of MDD.

Voice over: The sadness,

Superscript: These are not all the symptoms of MDD.

Voice over: loss of interest, low energy,

Superscript: These are not all the symptoms of MDD.

Voice over: trouble with sleep,

Superscript: These are not all the symptoms of MDD.

Voice over: and difficulty concentrating.

Voice over: I knew I had to change something…

Voice over: For myself, and those who care about me.

Superscript: Trintellix logo. What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: I spoke to my doctor and learned about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

Superscript: Trintellix logo. Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

Voice over: TRINTELLIX was shown to help reduce the overall symptoms of MDD.

Superscript: TRINTELLIX logo + STORYTELLERS = TRINTELLERS. TRINTELLLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Voice over: We, as TRINTELLERS, are a collection of actual people with MDD who are taking Trintellix, ready to shed light on the realities of MDD, and our personal journeys.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Voice over: Hopefully our stories encourage you and other people with MDD to have an open conversation with your doctor about TRINTELLIX.

Voice over: It’s never too late to find the treatment plan that is right for you.

Superscript: Download the doctor discussion guide. Talk to your doctor today. Individual results may vary. Only a doctor can diagnose and treat MDD.

Voice over: Download the doctor discussion guide. Then talk to your doctor today.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to the Medication Guide located at the bottom of this video player and talk to your doctor.

You are encouraged to report the negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark

Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2022 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).

US-VOR-0983v1.0 09/22

New TRINTELLERS discuss the impact of their MDD symptoms.

Four new TRINTELLERS join the team to share their perspective on living with MDD.

These TRINTELLERS want to remind you that you are not alone. 

Hear from: Jesus

A dog dad, a friend, and an amateur karaoke singer. After struggling with his MDD symptoms alone for many years, Jesus finally decided to talk to his doctor. Now, he's sharing his journey in hopes that it will encourage other people to seek the help they need.

This is one patient's personal experience. Individual results may vary.

Videos

Transcript

Videos

Jesus, a patient treated with TRINTELLIX

2:18
Jesus' Story
“I was dealing with my symptoms on my own, not knowing what was really going on… Looking back, I wish I had figured this out with my doctor earlier.”
Jesus, a patient treated with TRINTELLIX

2:38
Meet Jesus
“My life motto is to try and find the good things even in bad situations.”
Superscript: Jesus, a real patient with MDD. Jesus is a paid speaker for Takeda and Lundbeck.

Voice over: Before I found out I had depression, I was dealing with symptoms on my own, not knowing what was really going on.

Superscript: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Voice over: I was feeling sad, lost interest in things I used to like, and noticed a change in my weight. I was dealing with these and other symptoms and it really started to get to me. The people closest to me noticed that I was struggling, but it felt like no one truly understood what I was going through. Living with depression can be really hard, and I remember realizing that I couldn't continue like this on my own. I needed to do something about it. That’s what really convinced me to talk to a doctor, but it took time for me to find the right one who I felt I could trust.

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: And when I finally did, my doctor told me about TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder. He told me that TRINTELLIX worked and that it could be a good treatment for me to try.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Superscript: Medication may not be appropriate for everyone.

Voice over: Looking back, I wish I had figured this out with my doctor earlier.

Superscript: Individual results may vary

Voice over: There's good days and there's bad days, it's never perfect.

Superscript: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

Voice over: But having a treatment that has given some relief from my MDD has been a real change.

Voice over: Overall, this journey has been a big shift, and I'm looking forward to seeing what comes next.

Superscript: Hear from more real patients living with MDD who are taking TRINTELLIX (vortioxetine).

Superscript: Ruth

Superscript: Tatiana

Superscript: and talk to your doctor about finding a treatment plan that’s right for you.

Medication may not be appropriate for everyone.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0740v1.0 11/21

Superscript: What can life with MDD* look like? *Major Depressive Disorder

Superscript: Well, that depends.

Superscript: For Jesus, it looks like this:

Superscript: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Jesus, a real patient with MDD. Jesus is a paid speaker for Takeda and Lundbeck.

Voice over: My name is Jesus.

Superscript: Jesus is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Voice over: I’m a dog dad, a friend, and sometimes I’m an amateur karaoke singer.

Voice over: I also have depression, which has many symptoms and it can darken my days.

Voice over: My life motto is to try and find the good things even in bad situations.

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: After going to my doctor for help, they prescribed TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

Superscript: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

Voice over: Since then, I’ve felt relief from my overall MDD symptoms.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all the medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects.

Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Voice over: I’m sharing my story because I want to help connect with other people who have depression

Superscript: Talk to your doctor to find a treatment plan that’s right for you. Medication may not be appropriate for everyone.

Voice over: to show them that they're not alone and that their condition does not define them. So talk to your doctor to find a treatment plan that’s right for you.

Superscript: Hear more patient stories.

Superscript: TRINTELLIX + STORYTELLERS = TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0745v1.0 11/21

A dog dad, a friend, and an amateur karaoke singer. After struggling with his MDD symptoms alone for many years, Jesus finally decided to talk to his doctor. Now, he's sharing his journey in hopes that it will encourage other people to seek the help they need.

This is one patient's personal experience. Individual results may vary.

Hear from: Ruth

Ruth knows that the simple things in life are often the best like reading her favorite book, completing a new puzzle and spending time with her family.

Trying to deal with her MDD symptoms has really been a struggle. She never gave up working with her doctor to find the right treatment plan for her, and she hopes that sharing her story will encourage other people to do the same.

This is one patient's personal experience. Individual results may vary.

Videos

Transcript

Videos

Ruth, a patient treated with TRINTELLIX

2:21
Ruth's Story
“I think about all the people who are probably like me. People who are struggling, just want to find a way to feel better…”
Ruth, a patient treated with TRINTELLIX

2:54
Meet Ruth
“My motto is to embrace gratitude and try my best everyday”
Superscript: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Voice over: When I think about depression, I think about all the people who are probably like me. People who are struggling, and just want to find a way to feel better.

Superscript: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Superscript: Ruth, a real patient with MDD. Ruth is a paid speaker for Takeda and Lundbeck.

Voice over: Because of my depression I can experience feelings of sadness.

Superscript: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Voice over: I find myself uninterested in the things I usually care about, and I often feel tired.

Voice over: I think having support is important.

Voice over: My sister was always there for me. She would listen to me talk about the difficulties I faced and even helped me look into options to talk to my doctor about.

Voice over: I started working with my doctor to try to find a treatment plan that worked for me, but it didn't happen in a day. Eventually, we found one, but it took a little while to get there.

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: One day my doctor and I discussed TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, and decided it could be a good fit for me.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Superscript: Individual results may vary.

Voice over: Sure, some days are still harder than others, but having a plan in place and working with my doctor has helped manage my MDD.

Voice over: I know that if I continue being open with the people in my life who are there to support me, and stick to my plan, I'll be able to continue on this journey

Voice over: Even though I know there will be challenges, I'm looking forward to seeing what's next.

Superscript: Hear from more real patients living with MDD who are taking TRINTELLIX (vortioxetine).

Superscript: Jesus

Superscript: Tatiana

Superscript: and talk to your doctor about finding a treatment plan that’s right for you. Medication may not be appropriate for everyone.

For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0731v1.0 11/21

Superscript: What can life with MDD* look like? *Major Depressive Disorder

Superscript: Well, that depends.

Superscript: For Ruth, it looks like this:

Superscript: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Superscript: Ruth, a real patient with MDD. Ruth is a paid speaker for Takeda and Lundbeck.

Voice over: My name is Ruth.

Superscript: Ruth is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all the symptoms of MDD.

Voice over: I’m an avid reader, I love to travel and work on puzzles. I also have depression, and it can really get in the way. A life with depression comes with challenges, and some days are harder than others. But my life motto has always been to embrace gratitude and try my best every day.

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: My doctor prescribed TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Superscript: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

Voice over: Ever since taking TRINTELLIX, I've noticed an improvement in my overall MDD symptoms.

Voice over: I’m sharing my story because I want to encourage others to not give up, and to seek whatever help they may need.

Superscript: Talk to your doctor to find a treatment plan that’s right for you.

Superscript: Medication may not be appropriate for everyone.

Voice over: So talk to your doctor to find a treatment plan that's right for you.

Superscript: Hear more patient stories.

Superscript: TRINTELLIX + STORYTELLERS = TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Superscript: TRINTELLIX + STORYTELLERS = TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0736v1.0 11/21

Ruth knows that the simple things in life are often the best like reading her favorite book, completing a new puzzle and spending time with her family.

Trying to deal with her MDD symptoms has really been a struggle. She never gave up working with her doctor to find the right treatment plan for her, and she hopes that sharing her story will encourage other people to do the same.

This is one patient's personal experience. Individual results may vary.

Hear from: Tatiana

Tatiana spends time traveling and catching up on the latest binge-worthy TV show. She worked closely with her doctor to find the right MDD treatment plan for her, but before she did, she struggled for years. Now, she hopes to be an advocate for people with MDD, because she knows the importance of seeing others who are going through a similar experience.

This is one patient's personal experience. Individual results may vary.

Videos

Transcript

Videos

Tatiana, a patient treated with TRINTELLIX

2:21
Tatiana’s Story
“It’s hard to look back on, but I had honestly forgotten what it felt like to not be sad all the time.”
Tatiana, a patient treated with TRINTELLIX

2:33
Meet Tatiana
“My motto is it’s okay not to be okay.”
Superscript: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD. Tatiana, a real patient with MDD. Tatiana is a paid speaker for Takeda and Lundbeck.

Voice over: My road to find the right treatment plan for my depression wasn’t easy.

Voice over: It's hard to look back on, but I had honestly forgotten what it felt like to not be sad all the time.

Superscript: These are not all of the MDD symptoms you may experience.

Voice over: There are lots of symptoms that come with my type of depression, but I personally dealt with feelings of sadness, a loss of interest in things that I like, and it was hard for me to concentrate.

Superscript: These are not all of the MDD symptoms you may experience.

Voice over: I realized that I couldn't handle these and other MDD symptoms on my own.

Voice over: I had moved a lot, so I was changing doctors all the time, which made it harder to find the treatment that was right for me.

Voice over: But I knew I couldn't give up.

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: That's when I began working with my current doctor who prescribed me TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

Superscript: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

Voice over: Now that I've been on TRINTELLIX, I've seen relief from my overall MDD symptoms.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Voice over: It's not easy, but I want people to know that there may be a light at the end of the tunnel.

Voice over: You've gotta be open about how you're feeling, gotta speak up to your doctor, continue working together to find the right plan for you.

Voice over: I'm going to continue on this journey, because it's worth it to me.

Superscript: Hear from more real patients living with MDD who are taking TRINTELLIX (vortioxetine).

Superscript: Jesus

Superscript: Ruth

Superscript: and talk to your doctor about finding a treatment plan that’s right for you. Medication may not be appropriate for everyone.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0730v1.0 11/21

Superscript: What can life with MDD* look like? *Major Depressive Disorder

Superscript: Well, that depends.

Superscript: For Tatiana, it looks like this:

Superscript: Tatiana is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, considerable change in weight, trouble with sleep, and difficulty concentrating. These are not all of the symptoms of MDD. Tatiana, a real patient with MDD. Tatiana is a paid speaker for Takeda and Lundbeck.

Voice over: My name is Tatiana. When I'm not traveling, I like to play video games, watch TV, and hang out with my cat. I also have depression, which can make me feel negative about myself and hopeless. I always remind myself "it's okay to not be okay". But that doesn't mean you have to face challenges alone.

Superscript: What is TRINTELLIX? TRINTELLIX (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: After going to my doctor for help, they prescribed me TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Superscript: Individual results may vary.

Voice over: Since then, I feel like I've learned how to better manage my MDD, and finding the right treatment for me was a big part of that. I'm sharing my story because I want others to know what having MDD may look like,

Superscript: Medication may not be appropriate for everyone. Individual results may vary.

Voice over: and encourage them to reach out to a doctor the way that I did.

Superscript: Medication may not be appropriate for everyone.

Voice over: You are not alone. Talk to your doctor to find a treatment plan that's right for you.

Superscript: Hear more patient stories.

Superscript: TRINTELLIX + Storytellers = TRINTELLERS

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to Medication Guide located at bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2021 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (877-825-3327).

US-VOR-0748v1.0 11/21

Tatiana spends time traveling and catching up on the latest binge-worthy TV show. She worked closely with her doctor to find the right MDD treatment plan for her, but before she did, she struggled for years. Now, she hopes to be an advocate for people with MDD, because she knows the importance of seeing others who are going through a similar experience.

This is one patient's personal experience. Individual results may vary.

Hear from: DeAnna

DeAnna's struggle with MDD changed when she opened up to her loved ones. Now this mom, gamer, and boat fan is telling her story in the hope it can make others feel less alone.

This is one patient's personal experience. Individual results may vary.

Videos

Transcript

Videos

DeAnna, a patient treated with TRINTELLIX

2:21
Meet DeAnna
"For the longest time I tried handling it on my own, until the people I love saw I was struggling and I decided to get help."
DeAnna, a patient treated with TRINTELLIX

2:21
DeAnna's Story
“But before giving up, I called my doctor's office again, and they told me about the TRINTELLIX Savings Card. Enrollment was easy from sign up to pick up.”
Voice over: For a long time I tried dealing with depression on my own.

Superscript: on my own

Voice over: But eventually it became clear I was keeping too much inside.

Voice over: And my friends and family could tell that I was struggling.

Superscript: shared how I was feeling

Voice over: Once I shared how I was feeling with the people I love, getting the help I needed felt much more manageable.

Voice over: And it took some time, but I found a doctor that I was able to build a great relationship with.

Voice over: We’ve worked together for years now, and in that time my treatment plan has evolved.

Voice over: I was frustrated at first, but she helped me understand that progress can be slow, and not to get discouraged.

Voice over: We would try different ways of coping with MDD, and each time we met I would tell her what’s working and what’s not, so we could keep moving in the right direction.

Superscript: right direction

Voice over: One day we were checking in and I was telling her how I still wasn’t feeling like we had gotten it right.

Superscript: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: She agreed and suggested I try TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder or MDD.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood, behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric, and depression medicines, to avoid a potentially life-threatening condition.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Manic episodes can occur in people with bipolar disorder. Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: Common side effects include nausea, constipation, and vomiting.

Voice over: I hope that hearing my story helps encourage people at all stages of their MDD journey to always be honest with their doctor and keep that line of communication open. It may take some time and there will be twists and turns, but you deserve to find the treatment plan that works best for you.

Superscript: works BEST for YOU

Superscript: Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you.

Individual results may vary. Only a doctor can diagnose and treat MDD.

Voice over: Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you.

Superscript: TRINTELLIX vortioxetine 5mg•10mg•20mg tablets

Superscript: +

Superscript: Storytellers

Superscript: =

Superscript: Trintellers

Superscript: Trintellers
TRINTELLIX + Storytellers

TRINTELLERS are real MDD patients treated with TRINTELLIX who are here to share their stories with others.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to the Medication Guide located at bottom of this video player and talk to your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2023 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).

US-VOR-0985v1.0 02/23
Superscript: How DeAnna Saved on Medication

Voice over: When considering medications, I always ask things like: will it work for me? What are the side effects? And, as a single mom: can I afford it?

Superscript: DeAnna is a real patient with Major Depressive Disorder (MDD). DeAnna is a paid speaker for Takeda and Lundbeck.

Voice over: It was when I was at my darkest, lowest point, that I knew I needed to take action.

Superscript: DeAnna is diagnosed with a certain type of depression called Major Depressive Disorder (MDD). Symptoms of MDD may include sadness, loss of interest, difficulty concentrating, low energy, and excessive guilt. These are not all the symptoms of MDD.

Voice over: So, I talked to my doctor and she recommended TRINTELLIX, a prescription medicine for adults with a type of depression called Major Depressive Disorder, or MDD.

Superscript: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: TRINTELLIX was shown to help reduce the overall symptoms of MDD. And there were some nice surprises ahead—including the TRINTELLIX Savings Card.

Superscript: Overall score of symptom reduction was measured on a standardized depression rating scale in clinical trials. Individual results may vary.

Voice over: Antidepressants, like TRINTELLIX, may increase suicidal thoughts and actions in some people 24 years of age and younger.

Superscript: TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger. TRINTELLIX is not approved for children under 18.

Voice over: Call your doctor right away if you have new or worsening depression symptoms, unusual changes in mood,...

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: ...behavior or thoughts, or suicidal thoughts or actions while taking it.

Superscript: Call your doctor or get emergency help right away if you have new or worsening depression symptoms, new or sudden changes in mood, behavior, thoughts or feelings, or suicidal thoughts or actions.

Voice over: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Superscript: Do not take it if you take MAOIs, or if you are allergic to vortioxetine or any other ingredients in TRINTELLIX.

Voice over: Tell your doctor about all medicines you take, including migraine, psychiatric,...

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: ...and depression medicines, to avoid a potentially life-threatening condition.

Superscript: Tell your doctor about all your medical conditions and all the medicines you take. Taking TRINTELLIX with certain medicines can result in a life-threatening condition.

Voice over: Increased risk of bleeding and bruising may occur, especially if taken with aspirin, NSAID pain relievers, warfarin, or blood thinners.

Superscript: TRINTELLIX may increase risk of bleeding. Tell your doctor right away about any unusual bleeding or bruising.

Voice over: Manic episodes can occur in people with bipolar disorder.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Superscript: Call your doctor if you have any new or sudden changes in mood, behavior, thoughts, or feelings.

Voice over: Suddenly stopping TRINTELLIX may cause you to have serious side effects.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Superscript: Suddenly stopping TRINTELLIX may cause you to have serious side effects. Visual problems may occur in some people. TRINTELLIX may cause low sodium levels and sexual problems.

Voice over: Common side effects include nausea, constipation, and vomiting.

Superscript: Common side effects of TRINTELLIX include nausea, constipation, and vomiting.

Voice over: After talking with my doctor, I wanted to give TRINTELLIX a try, but learned that I would have had a high copay with my insurance. I almost walked away.

Superscript: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: But before giving up, I called my doctor’s office again, and they told me about the TRINTELLIX Savings Card. Enrollment was easy from sign up to pick up. You can even do it yourself: simply check your eligibility on the TRINTELLIX website and activate your Savings Card.

Superscript: Restrictions apply. See the TRINTELLIX Savings Card for Eligibility Requirements and Terms & Conditions. Commercially insured patients only.

Voice over: Getting the Savings Card was a win for me. Depending on your eligibility, you can get either a 30- or a 90-day prescription for as little as $10.

Superscript: Restrictions apply. See the TRINTELLIX Savings Card for Eligibility Requirements and Terms & Conditions. Commercially insured patients only

Voice over: I’m glad I talked to my doctor because, with TRINTELLIX, I feel I now have more control over my MDD.

Superscript: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: It was small steps at first, but eventually...

Superscript: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: ...TRINTELLIX helped improve my MDD.

Superscript: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: I’m thankful for TRINTELLIX and the Savings Card. Without them, I wouldn’t be where I am today.

Superscript: What is TRINTELLIX? TRINTELLIX® (vortioxetine) is used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). By prescription only.

Voice over: Ask your doctor about TRINTELLIX and the Savings Card to see if it could be right for you.

Superscript: Restrictions apply. See the TRINTELLIX Savings Card for Eligibility Requirements and Terms & Conditions. Commercially insured patients only.

Voice over: Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you.

Superscript: Hear from more people living with MDD and talk to your doctor about finding the right treatment plan for you. Individual results may vary. Only a doctor can diagnose and treat MDD.

Superscript: TRINTELLIX logo.

Superscript: +

Superscript: Storytellers

Superscript: =

Superscript: Trintellers

Superscript: Trintellers (TRINTELLIX + Storytellers)

TRINTELLERS are real patients with MDD treated with

TRINTELLIX who are here to share their stories with others.

Superscript: For more safety information, including Boxed WARNING for Suicidal Thoughts and Actions, please click on the link to the Medication Guide located at the bottom of this video player and talk to your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Superscript: TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under License by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2023 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved.

1-877-TAKEDA-7 (1-877-825-3327).

US-VOR-1327v1.0 09/23

DeAnna's struggle with MDD changed when she opened up to her loved ones. Now this mom, gamer, and boat fan is telling her story in the hope it can make others feel less alone.

This is one patient's personal experience. Individual results may vary.

Ready to take the next step in your journey?

Better communication may lead to finding the treatment that's right for you. Filling out a doctor discussion guide can help you understand what you’re feeling and serve as a guide for an open and honest conversation with your doctor about your treatment needs.

IMPORTANT SAFETY INFORMATION about TRINTELLIX

Suicidal Thoughts & Actions

TRINTELLIX and other antidepressants increase the risk of suicidal thoughts and actions in people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. Call your doctor or get emergency help right away to report any of these, or if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

  • are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • are taking, or have stopped taking within the last 14 days, a medicine called a Monoamine Oxidase Inhibitor (MAOI), including the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

  • about all your medical and other health conditions
  • if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX
  • if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; lithium; tramadol, fentanyl, meperidine, methadone, or other opioids; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; diuretics; medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs); or medicines used to treat seizures or convulsions.

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

  • Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart-beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
  • Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
  • Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
  • Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
  • Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
  • Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in their blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
  • Sexual problems: Taking TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your doctor if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.

The most common side effects of TRINTELLIX include:

  • nausea
  • constipation
  • vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1‑800‑FDA‑1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.

 

There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at 

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.