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Yeah, it helps to know you’re not alone.

TRINTELLIX is a prescription medication used to treat Major Depressive Disorder (MDD) in adults that has helped reduce the multiple symptoms of depression (MDD) based on an overall score on a standardized depression rating scale in multiple 6-8 week studies and one maintenance study vs. sugar pill.

Hear David tell it like it is

David's story

David’s reflections on facing depression (MDD) with TRINTELLIX

For a long time, David had his depression (MDD) under control. But when his depression came flooding back, David knew he just couldn't do it alone any longer. Watch David speak candidly about his journey, and how he sought help from his healthcare professional.

Individual results may vary.

Transcript

You could say I’m interested in connecting with others. I’ve always been that way. I’m always asking, “ What’s going on? How are you doing? What’s your life about?” I’m David, I’m 53 years old. I’m a bit of a people person.

I used to run a successful animal sanctuary, and working with animals is still something that I’m passionate about—I’m even writing a book for pet owners. I like cycling and spinning, and I like to get out and see what’s going on in the world around me.

You know, maybe I’m so interested in people because I’ve also learned that life can be a struggle. Sometimes what hurts the most can’t be seen on the outside.

I had this all-encompassing sadness throughout every aspect of my life. I felt tired, worthless, alone—even though I grew up in a large family that was no stranger to mental illness. People were always around, but I just wanted to avoid them . I wasn’t sleeping well, and most of the time I couldn’t think straight. I was even having difficulty concentrating.

It was during a session with my therapist that I first learned about my depression, or MDD.

My diagnosis actually brought with it some clarity about what I had been going through. It was good to talk to a doctor about the things I was feeling.

I began to feel like my depression was getting under control and I was trying to move forward. Years went by, and I opened an animal sanctuary with my wife, and I spent more and more time focusing on the work there, and I thought that I had left things behind.

It’s kind of interesting that our sanctuary made national news, and things began to move really, really fast. It was an inward struggle, you know? And I stayed busy just so I would feel “okay.”

But then, there was this time—and I remember it well—I was on vacation with family, and I found myself alone, on a beach. Once I was alone and quiet, it all came flooding back, and I felt my depression more than ever before. I just couldn’t do it any longer on my own.

I talked to my doctor about my past major depressive episodes, and the symptoms I was experiencing…

…it was these overwhelming feelings of sadness and worthlessness, and being tired but not able to sleep. It was also affecting my ability to concentrate and make decisions, and I saw how my depression was more than sadness.

For treatment, my doctor suggested I try a prescription medication called TRINTELLIX. He explained that it may help manage my depression. After starting on TRINTELLIX, I did notice that overall my depression symptoms were beginning to improve.

I started feeling better, and it felt like my depression was less of a struggle. I sensed that changes were happening in my symptoms and my treatment was making a difference for me.

The way I see it, depression is always there, following me around, always something to deal with. That being the case, I’ve learned over time how to connect with my doctor about my depression—including how I feel, think, and act.

I know this kind of sharing can be a struggle. Finally deciding to talk about my symptoms—it’s what helped me move forward with my doctor. It seems like a small choice but it can make a difference. I understand when I’m not facing my depression head on. I’ve seen how it can come back, and I know I need to be aware of what's going on within me.

I’m a people person. That’s why I ask questions—I know there are people out there like me. I talk to them all the time—and sometimes, when things aren’t working, we need to ask more questions. I’ve seen what can happen when we reach out and ask for help. It’s a connection worth making.

Important Safety Information

Suicidal Thoughts and Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.

Do not take TRINTELLIX if you:

  • Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days

TRINTELLIX may cause serious side effects including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.

Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (such as Coumadin® or Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.

Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.

TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.

Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.

Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.

Talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see accompanying Prescribing Information, including Medication Guide for TRINTELLIX.

Indication

TRINTELLIX is a prescription medicine used to treat Major Depressive Disorder—or MDD—in adults.

Continue to explore Trintellix.com for additional support and more information about TRINTELLIX.

David's Reflections on Facing Depression (MDD) With TRINTELLIX
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Transcript

You could say I’m interested in connecting with others. I’ve always been that way. I’m always asking, “ What’s going on? How are you doing? What’s your life about?” I’m David, I’m 53 years old. I’m a bit of a people person.

I used to run a successful animal sanctuary, and working with animals is still something that I’m passionate about—I’m even writing a book for pet owners. I like cycling and spinning, and I like to get out and see what’s going on in the world around me.

You know, maybe I’m so interested in people because I’ve also learned that life can be a struggle. Sometimes what hurts the most can’t be seen on the outside.

I had this all-encompassing sadness throughout every aspect of my life. I felt tired, worthless, alone—even though I grew up in a large family that was no stranger to mental illness. People were always around, but I just wanted to avoid them . I wasn’t sleeping well, and most of the time I couldn’t think straight. I was even having difficulty concentrating.

It was during a session with my therapist that I first learned about my depression, or MDD.

My diagnosis actually brought with it some clarity about what I had been going through. It was good to talk to a doctor about the things I was feeling.

I began to feel like my depression was getting under control and I was trying to move forward. Years went by, and I opened an animal sanctuary with my wife, and I spent more and more time focusing on the work there, and I thought that I had left things behind.

It’s kind of interesting that our sanctuary made national news, and things began to move really, really fast. It was an inward struggle, you know? And I stayed busy just so I would feel “okay.”

But then, there was this time—and I remember it well—I was on vacation with family, and I found myself alone, on a beach. Once I was alone and quiet, it all came flooding back, and I felt my depression more than ever before. I just couldn’t do it any longer on my own.

I talked to my doctor about my past major depressive episodes, and the symptoms I was experiencing…

…it was these overwhelming feelings of sadness and worthlessness, and being tired but not able to sleep. It was also affecting my ability to concentrate and make decisions, and I saw how my depression was more than sadness.

For treatment, my doctor suggested I try a prescription medication called TRINTELLIX. He explained that it may help manage my depression. After starting on TRINTELLIX, I did notice that overall my depression symptoms were beginning to improve.

I started feeling better, and it felt like my depression was less of a struggle. I sensed that changes were happening in my symptoms and my treatment was making a difference for me.

The way I see it, depression is always there, following me around, always something to deal with. That being the case, I’ve learned over time how to connect with my doctor about my depression—including how I feel, think, and act.

I know this kind of sharing can be a struggle. Finally deciding to talk about my symptoms—it’s what helped me move forward with my doctor. It seems like a small choice but it can make a difference. I understand when I’m not facing my depression head on. I’ve seen how it can come back, and I know I need to be aware of what's going on within me.

I’m a people person. That’s why I ask questions—I know there are people out there like me. I talk to them all the time—and sometimes, when things aren’t working, we need to ask more questions. I’ve seen what can happen when we reach out and ask for help. It’s a connection worth making.

Important Safety Information

Suicidal Thoughts and Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.

Do not take TRINTELLIX if you:

  • Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days

TRINTELLIX may cause serious side effects including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.

Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (such as Coumadin® or Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.

Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.

TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.

Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.

Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.

Talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see accompanying Prescribing Information, including Medication Guide for TRINTELLIX.

Indication

TRINTELLIX is a prescription medicine used to treat Major Depressive Disorder—or MDD—in adults.

Continue to explore Trintellix.com for additional support and more information about TRINTELLIX.

Watch other patient stories

TRINTELLIX (vortioxetine) is a prescription medicine used to treat Major Depressive Disorder (MDD) in adults.

TRINTELLIX helped reduce the multiple symptoms of depression (MDD) based on an overall score on a standardized depression rating scale in multiple 6‑8 week studies and one maintenance study vs. sugar pill.

Individual results may vary.

In short-term studies, the therapeutic effect of TRINTELLIX was generally seen starting at week 2, with full effect generally not seen until week 4, or later.

Patients featured are on TRINTELLIX at time of interview.

tAccess support program: helpful tips, support, and savings

Savings and so much more

With the tAccess Support Program, eligible patients may pay as little as $10* for each monthly prescription, and receive other support like motivational calls, texts and emails.

Join tAccess

*Must meet eligibility requirements. Eligible patients will save up to $100 per 30‑day prescription. Savings will apply after patients pay for the first $10. 

Track your depression (MDD) symptoms

SYMPTOM CHECKLIST

Feeling blah?

Depression is multiple symptoms. Fill out the symptom checklist then tell your doctor about all of your symptoms.

Check your symptoms

Important Safety Information About TRINTELLIX

+

Suicidal Thoughts and Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.

Do not take TRINTELLIX if you:

  • Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days

TRINTELLIX may cause serious side effects including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.

Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.

Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.

TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.

Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.

Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.

Talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Indication for TRINTELLIX

TRINTELLIX is a prescription medicine used to treat Major Depressive Disorder (MDD) in adults.

Please see Prescribing Information, including Medication Guide for TRINTELLIX.