Patient portrayal.
TRINTELLIX® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).
The list price for TRINTELLIX is $466.35 for a 30-day prescription.* Commercially insured patients may pay as little as $10.00 for either a 30-day or 90-day prescription with the TRINTELLIX Savings Card.†
For more information, visit How Much Does TRINTELLIX Cost?
*As of 01/03/2023
†Only commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.
The TRINTELLIX Savings Card offer cannot be used if you are a beneficiary of, or any part of your prescription is covered by: (1) any federal, state, or government-funded healthcare program (for example, Medicare, Medicaid, TRICARE), including a state pharmaceutical assistance program (the Federal Employees Health Benefits (FEHB) Program is not a government-funded healthcare program for purposes of this offer), (2) the Medicare Prescription Drug Program (Part D), or if you are currently in the coverage gap, or (3) insurance that is paying the entire cost of the prescription. Patient must be age 18 or older and have a valid prescription for TRINTELLIX. Cash patients are not eligible for the TRINTELLIX Savings Card.
If eligible, you can register for the TRINTELLIX Savings Card here. If you are having trouble signing up online or have questions about eligibility requirements, you can also call 1-866-279-0287 to register.
If you’re an eligible patient signing up for a TRINTELLIX Savings Card online, you will receive your activated card online immediately. You can print the Savings Card and use it right away. If you’re having trouble activating your Savings Card online, please call 1-866-279-0287 to activate it.
If you received a TRINTELLIX Savings Card from your healthcare professional in the brochure, you can activate it here, or call 1-866-279-0287. You will be asked for the ID number on the card.
Once you’ve activated your TRINTELLIX Savings Card, take your prescription and your savings card to your pharmacist.*
*Only commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.
With the TRINTELLIX Savings Card, eligible patients can save on TRINTELLIX prescriptions and refills. You also get free access to the TRINTELLIX Support Program, tAccess, which provides support for people with MDD.
See "Am I eligible for the TRINTELLIX Savings Card?" above.
The tAccess Support Program is personalized support for patients on TRINTELLIX therapy. The purpose of the program is to help patients stay on track with their treatment as directed by their healthcare professional.Patients who enroll in the tAccess Support Program can expect to receive:
*All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.
If the pharmacy has difficulty processing your card, have the pharmacy follow the steps on the back of your TRINTELLIX Savings Card. The pharmacy can also call 1-866-279-0287 for processing questions.
If eligible and your pharmacist cannot process your card, or doesn’t accept your card and you’ve already paid for your prescription, please visit www.patientrebateonline.com and follow the instructions for savings. If you need further information, call 1-866-279-0287.
Patient mail-in rebate forms for eligible patients and information on how to complete and submit them are available at www.patientrebateonline.com. You may also request one by calling 1-866-279-0287.
For general information about TRINTELLIX Savings Cards, including information for getting a replacement card, call 1-866-279-0287.
Help At Hand is a patient assistance program that provides access to medicine for eligible patients with financial need. Visit Help At Hand to request an application. Restrictions apply.
Patient mail-in rebate forms and information on eligibility and how to complete and submit are available at www.patientrebateonline.com. You may also request one by calling 1-866-279-0287.
Visit Takeda Help At Hand to learn more.
Are you still there? Don’t miss out on the savings offer! Click or scroll to complete the form to sign up for savings, if eligible
Suicidal Thoughts & Actions
TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children under 18. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings. Call your doctor or get emergency help right away if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.
Who should not take TRINTELLIX?
Do not start or take TRINTELLIX if you:
Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.
What should I tell my doctor before taking TRINTELLIX?
Before taking TRINTELLIX, tell your doctor:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; opioids (such as fentanyl and tramadol); lithium; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; and diuretics.
What are the possible side effects of TRINTELLIX?
TRINTELLIX may cause serious side effects, including:
The most common side effects of TRINTELLIX include:
These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.
TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).
There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at
For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.
Suicidal Thoughts & Actions
TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children under 18. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings. Call your doctor or get emergency help right away if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.
Who should not take TRINTELLIX?
Do not start or take TRINTELLIX if you:
Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.
What should I tell my doctor before taking TRINTELLIX?
Before taking TRINTELLIX, tell your doctor:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; opioids (such as fentanyl and tramadol); lithium; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; and diuretics.
What are the possible side effects of TRINTELLIX?
TRINTELLIX may cause serious side effects, including:
The most common side effects of TRINTELLIX include:
These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.
TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).
There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at
For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.