Savings & support

Patient portrayal.

TRINTELLIX^® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

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Are you under the age of 18, are you covered by Medicare, Medicaid, or any other government insurance, or are you a cash paying patient? (Federal Employees Health Benefits (FEHB) is not included for purposes of this offer.)

Yes, I am under the age of 18, covered by government insurance, or a cash paying patient.

No, I am age 18 or older and covered by private insurance.

You are not eligible for a Savings Card, but you can still sign up for tAccess for support if you are age 18 or older

Remember you can get tips and advice, and inspirational messages when you sign up for tAccess.

You are eligible for the tAccess program, including the Savings Card

Remember you can get tips and advice, and inspirational messages when you sign up for tAccess.

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I am not taking TRINTELLIX but would like to learn more

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I am new to TRINTELLIX and I want to learn more about the tAccess Savings and Support Program

By checking this box and clicking the "Sign up now" button, you certify that you are 18+ years of age and give permission to use your personal information to receive product and disease state information from Takeda Pharmaceuticals U.S.A., Inc., its affiliates, service providers, and co-promotion partners. You may opt out of the email communications at any time by clicking on the unsubscribe link in the email communications. All personal information you have provided will be kept confidential and will not be used or distributed for any purpose other than what is explained in our Privacy Notice. We encourage you to read our Privacy Notice by clicking on this link: Takeda Privacy Notice. This consent will be in effect until such time as you opt out.

Text messages and push notifications:

By checking this box, you are opting to receive inspiring messages to help you along the way, and agree as set forth below.

By checking this box, you are opting to receive a mobile version of the tAccess Savings Card (if eligible), as well as medication refill reminders and savings offer messages, and agree as set forth below.

Yes, I agree to the SMS and Notifications Terms & Conditions of the tAccess Support Program. I hereby consent to receive text messages at the telephone number provided above. I understand this consent is not a condition of purchase or use of TRINTELLIX or any product or service. I understand that standard message and data rates apply and that I may revoke this consent by texting STOP at any time.

By opting in to text messages and push notifications from the tAccess Support Program (the “Program”), you consent to receiving approximately 10 text messages and/or push notifications per month from EngagedMedia using autodialer technology. Consent is not a condition of purchase. Such messages may be marketing or non-marketing messages and may include, for example, patient education information, surveys, prescription reminders, and prescription savings opportunities. Carriers are NOT liable for delayed or undelivered messages.
To stop receiving text messages, text STOP to 36395 or the short code from which you received a message. DOING SO WILL ONLY OPT YOU OUT OF TEXT MESSAGES FROM THE PROGRAM; you will remain opted in to any other Takeda text message program(s) to which you separately opted in. If receiving Program push notifications, you may unsubscribe at any time by going into the digital wallet on your device and disabling push notifications in the digital wallet Program pass or by removing the digital wallet Program pass from your device.
To request more information or to obtain help, text HELP to 36395 or the short code from which you received a Program text message. You can also call customer service at 1-866-279-0287.
By opting in to text messages from the Program, you agree to sharing your phone number with EngagedMedia for the purpose of enrolling you into Program text messages.
You represent that you are the account holder for the mobile telephone number(s) that you provide to opt in to text messages from the Program. You are responsible for notifying Takeda immediately if you change your mobile telephone number. You may notify Takeda of a number change by re-opting into Program text messages.
Message and data rates may apply to each text message sent or received in connection with the Program, as provided in your mobile telephone service rate plan, in addition to any applicable roaming charges. Charges are both billed and payable to your mobile service provider or deducted from your prepaid account. Takeda does not impose a separate fee for sending text messages.
Data obtained from you in connection with the Program may include your telephone number; your carrier's name; the date, time, and content of your text messages; and device information. This data may be used to administer the Program. Please read Takeda’s Privacy Notice, which is incorporated by reference into these Terms and Conditions.
In addition to the data use practices described in the Privacy Notice, Takeda may send you Program-related push notifications. Your device’s location will not be known or tracked by Takeda or its service providers or co-promotion partners. Nonetheless, you may opt out of geofencing and receiving these notifications at any time by (1) disabling location services for your digital wallet app in your device’s settings, (2) disabling notifications (i.e., automatic updates) within the digital wallet app, or (3) removing the tAccess Savings Card from your digital wallet by selecting “Remove Pass” within the digital wallet app.
Neither Takeda nor EngagedMedia will be liable for any delays in the receipt of any SMS messages, as delivery is subject to effective transmission from your network operator.
This service is available only on US participating mobile carriers.
You agree to indemnify Takeda and EngagedMedia in full for all claims, expenses, and damages related to or caused in whole or in part by your failure to notify us if you change your telephone number, including but not limited to all claims, expenses, and damages related to or arising under the Telephone Consumer Protection Act.
NO CLASS ACTIONS: you may only bring individual claims. Under no circumstance are you allowed to bring a claim as a punitive or named plaintiff or a class member in a class. Class action lawsuits, class-wide arbitrations, private attorney-general actions, and any other proceedings where someone acts in a representative capacity are not allowed. Any combining of individual proceedings must have the consent of all parties.
Takeda may suspend or terminate your receipt of text messages if it believes you are in breach of these Terms and Conditions. Your receipt of text messages is also subject to termination in the event that your mobile telephone service terminates or lapses. Takeda reserves the right to modify or discontinue, temporarily or permanently, all or any part of the text messaging services you receive, with or without notice.
Takeda may revise, modify, or amend these Terms and Conditions at any time. Any such revision, modification, or amendment shall take effect when it is posted to the Trintellix website and digital wallet Program pass. You agree to review these Terms and Conditions periodically to ensure that you are aware of any changes. Your continued consent to receive text messages will indicate your acceptance of those changes.
Takeda may be required to contact you if you report an adverse event or product quality complaint.
Takeda reserves the right to rescind, revoke, or amend the Program without notice at any time.
While Takeda makes reasonable efforts to include accurate, up-to-date information in the Program, Takeda makes no representations or warranties as to its accuracy. Takeda assumes no liability for any errors or omissions in the information communicated through the Program, and such information is not intended to make a diagnosis or to take the place of talking to a US healthcare professional.

Sorry we couldn't complete your registration at this time. Please contact 1-866-279-0287 to speak to a live agent who will be able to assist you.

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Frequently Asked Questions

The list price for TRINTELLIX is $466.35 for a 30-day prescription.* Commercially insured patients may pay as little as $10.00 for either a 30-day or 90-day prescription with the TRINTELLIX Savings Card.^†

For more information, visit How Much Does TRINTELLIX Cost?

*As of 01/03/2023

^†Only commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.

The TRINTELLIX Savings Card offer cannot be used if you are a beneficiary of, or any part of your prescription is covered by: (1) any federal, state, or government-funded healthcare program (for example, Medicare, Medicaid, TRICARE), including a state pharmaceutical assistance program (the Federal Employees Health Benefits (FEHB) Program is not a government-funded healthcare program for purposes of this offer), (2) the Medicare Prescription Drug Program (Part D), or if you are currently in the coverage gap, or (3) insurance that is paying the entire cost of the prescription. Patient must be age 18 or older and have a valid prescription for TRINTELLIX. Cash patients are not eligible for the TRINTELLIX Savings Card.

If eligible, you can register for the TRINTELLIX Savings Card here. If you are having trouble signing up online or have questions about eligibility requirements, you can also call 1-866-279-0287 to register.

If you’re an eligible patient signing up for a TRINTELLIX Savings Card online, you will receive your activated card online immediately. You can print the Savings Card and use it right away. If you’re having trouble activating your Savings Card online, please call 1-866-279-0287 to activate it.

If you received a TRINTELLIX Savings Card from your healthcare professional in the brochure, you can activate it here, or call 1-866-279-0287. You will be asked for the ID number on the card.

Once you’ve activated your TRINTELLIX Savings Card, take your prescription and your savings card to your pharmacist.*

*Only commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.

With the TRINTELLIX Savings Card, eligible patients can save on TRINTELLIX prescriptions and refills. You also get free access to the TRINTELLIX Support Program, tAccess, which provides support for people with MDD.

See "Am I eligible for the TRINTELLIX Savings Card?" above.

The tAccess Support Program is personalized support for patients on TRINTELLIX therapy. The purpose of the program is to help patients stay on track with their treatment as directed by their healthcare professional.Patients who enroll in the tAccess Support Program can expect to receive:

Savings Card* - pay as little as $10 for a 30- or 90-day prescription. Maximum savings of $100 on a 30-day or $300 on a 90-day script. Must meet eligibility requirements.
Mobile Wallet* - download your Savings Card and add it to your mobile wallet for your next refill. Must meet eligibility requirements.
Informative emails - Receive emails with tools to help empower you to have meaningful discussions with your doctor.
Inspiring texts and refill reminders when needed - Helpful messages and medication refill reminders sent to help you along the way.
Chats with a tAccess advisor - Call to receive information about the Savings Card and other support features (1‑844‑654‑TRIN), 8:00 am – 8:00 pm ET M-F.

*All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.

If the pharmacy has difficulty processing your card, have the pharmacy follow the steps on the back of your TRINTELLIX Savings Card. The pharmacy can also call 1-866-279-0287 for processing questions.
If eligible and your pharmacist cannot process your card, or doesn’t accept your card and you’ve already paid for your prescription, please visit www.patientrebateonline.com and follow the instructions for savings. If you need further information, call 1-866-279-0287.

Patient mail-in rebate forms for eligible patients and information on how to complete and submit them are available at www.patientrebateonline.com. You may also request one by calling 1-866-279-0287.

For general information about TRINTELLIX Savings Cards, including information for getting a replacement card, call 1-866-279-0287.

Help At Hand is a patient assistance program that provides access to medicine for eligible patients with financial need. Visit Help At Hand to request an application. Restrictions apply.

Mail-in rebate

Patient mail-in rebate forms and information on eligibility and how to complete and submit are available at www.patientrebateonline.com. You may also request one by calling 1-866-279-0287.

Help At Hand: patient assistance within reach

Need help affording your prescription?

Visit Takeda Help At Hand to learn more.

IMPORTANT SAFETY INFORMATION about TRINTELLIX

Suicidal Thoughts & Actions

TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children under 18. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings. Call your doctor or get emergency help right away if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

are allergic to vortioxetine or any of the ingredients in TRINTELLIX
take a Monoamine Oxidase Inhibitor (MAOI)
have stopped taking an MAOI in the last 14 days
are being treated with the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

about all your medical and other health conditions
if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX.
if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; opioids (such as fentanyl and tramadol); lithium; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; and diuretics.

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in your blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
Sexual problems: Taking antidepressants like TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your healthcare provider if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.

The most common side effects of TRINTELLIX include:

nausea
constipation
vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.

Suicidal Thoughts & Actions

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

are allergic to vortioxetine or any of the ingredients in TRINTELLIX
take a Monoamine Oxidase Inhibitor (MAOI)
have stopped taking an MAOI in the last 14 days
are being treated with the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

about all your medical and other health conditions
if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX.
if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in your blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
Sexual problems: Taking antidepressants like TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your healthcare provider if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.

The most common side effects of TRINTELLIX include:

nausea
constipation
vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.

This site is intended for use by U.S. residents ages 18 and older only.

TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

US-VOR-0992v1.0 03/23

Savings & support

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Frequently Asked Questions

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IMPORTANT SAFETY INFORMATION about TRINTELLIX

What is TRINTELLIX (vortioxetine)?

IMPORTANT SAFETY INFORMATION about TRINTELLIX

What is TRINTELLIX (vortioxetine)?

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Savings & support

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View SMS and Notifications Terms & Conditions

Frequently Asked Questions

How much does TRINTELLIX cost?

Am I eligible for the TRINTELLIX Savings Card?

How do I register for the TRINTELLIX Savings Card?

How do I activate and use my Savings Card?

What are the benefits of the TRINTELLIX Savings Card?

What should I expect to receive in the tAccess Support Program?

My pharmacy is having difficulty processing my Savings Card or cannot process my Savings Card. Can I still receive savings?

I've already paid for my prescription of TRINTELLIX. Is there a mail-in rebate available?

Who can I contact for general questions about the TRINTELLIX Savings Card, such as getting a replacement card?

If I don't qualify for the TRINTELLIX Savings Card, are there any assistance programs available to help cover my prescription?

Mail-in rebate

Need help affording your prescription?

IMPORTANT SAFETY INFORMATION about TRINTELLIX

What is TRINTELLIX (vortioxetine)?

IMPORTANT SAFETY INFORMATION about TRINTELLIX

What is TRINTELLIX (vortioxetine)?

You are about to leave us.trintellix.com and enter a website operated by an independent third party.

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