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Umm...antidepressant sexual side effects?

Ask your doctor if switching to TRINTELLIX may help.

Patient portrayal. Individual results may vary.

Antidepressant Sexual Side Effects

What are sexual side effects?

Antidepressants may cause sexual side effects, including:

  • Lack of sexual drive
  • Difficulty becoming aroused 
  • Difficulty achieving orgasm
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Antidepressant sexual side effects are a common problem.

You're not alone. Sexual side effects are common among many frequently used antidepressants. Patients who experience sexual side effects report it as one of the most troublesome side effects of their depression treatment.

"I felt very embarrassed...Why is this happening to me?"

-Male patient on difficulty discussing antidepressant sexual side effects with his doctor

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Don't be afraid to talk to your doctor.

Many people are reluctant to talk to their doctors about their antidepressant sexual side effects. While it can be an uncomfortable topic, you shouldn’t struggle in silence. Let your healthcare professional know about any side effects you’re experiencing.

“I know I need to be more open with my doctor on this topic.” 

–Female patient on talking to her doctor about antidepressant sexual side effects 

Can making a change to TRINTELLIX help?

In an 8-week clinical study, patients whose depression improved on sertraline (ZOLOFT®), citalopram (CELEXA®), or paroxetine (PAXIL®) but who were experiencing sexual side effects from their treatment were switched to either TRINTELLIX or escitalopram (LEXAPRO®).

Results from this study showed:

  • Patients switched to TRINTELLIX showed greater improvement in antidepressant sexual side effects compared to those who switched to escitalopram (LEXAPRO®)*
  • Patients switched to TRINTELLIX or escitalopram (LEXAPRO®) also maintained improvement in depression from their previous antidepressant therapy

Individual results may vary.

*Based on an average change from the overall score on a standardized sexual functioning questionnaire.

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Can TRINTELLIX cause sexual side effects?

As with other antidepressants, TRINTELLIX can be associated with sexual side effects during treatment. In 6- to 8-week clinical studies, up to 5% of Major Depressive Disorder (MDD) patients taking TRINTELLIX voluntarily reported sexual side effects. When proactively assessed in patients with normal sexual functioning in seven studies using a self-rated questionnaire, reports of sexual side effects from doses of TRINTELLIX 5 mg, 10 mg, 20 mg were 16%, 20%, 29% in men (N=212) respectively and 22%, 23% and 34% in females (N=226) respectively, compared to placebo rates of 14% in males (N=162) and 20% in females (N=135). 

Sexual side effects with antidepressants are known to be voluntarily underreported, in part because patients may be reluctant to discuss them. A self-rated questionnaire designed to identify sexual side effects was used in TRINTELLIX clinical trials to determine how many people actually experienced sexual side effects with TRINTELLIX.

See below for Important Safety Information, including Boxed WARNING for Suicidal Thoughts and Actions.

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tell it like it is

By using the Doctor Discussion Guide you can let your healthcare provider know about any side effects you're experiencing.

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Important Safety Information About TRINTELLIX


Suicidal Thoughts and Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.

Do not take TRINTELLIX if you:

  • Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days

TRINTELLIX may cause serious side effects including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.

Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.

Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.

TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.

Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.

Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.

Talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.


TRINTELLIX is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD) in adults.

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.