Patient portrayal.
TRINTELLIX® (vortioxetine) is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.
How much does TRINTELLIX cost?
The list price for TRINTELLIX is $466.35 for a 30-day prescription*
Takeda and Lundbeck are committed to ensuring you have the information you need for you and your doctor to make the best treatment decision for you. We know cost is an important consideration and that drug pricing can be complex.
If you have health insurance that covers drugs, your cost may be different. The actual price you would pay is based on several factors† including your insurance coverage, which pharmacy you use, and deductibles.
Select an insurance plan below to see the average monthly cost
Commercial (private) insurance
Average monthly out-of-pocket costs:
$58.54
Patients may be eligible to pay as little as
$10
for either a 30-day or 90-day prescription.‡
With the TRINTELLIX Savings Card, commercially insured patients may pay as little as $10 for either a 30-day or 90-day prescription.‡
Medicare Part D
Average monthly out-of-pocket costs:
$40.19
Patients may also be eligible for financial support through Help At Hand.
Medicaid
Average monthly out-of-pocket costs:
$1.05
Patients may also be eligible for financial support through Help At Hand.
VA/Department of Defense insurance
Average monthly out-of-pocket costs:
$61.00
Patients may also be eligible for financial support through Help At Hand.
No insurance
Average monthly out-of-pocket costs:
$466.35
Patients may also be eligible for financial support through Help At Hand.
To confirm your costs, call your insurance provider or ask your pharmacist.
*As of 01/03/2023
†Such as your insurance plan’s deductible and benefit reset, which pharmacy you use, co-pay, co-insurance, etc.
ǂOnly commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.
Join tAccess
By enrolling in tAccess (at no cost to you), you can customize your experience through support tools like chats with an advisor, texts and emails.
Prescription savings
Eligible patients may pay as little as $10 for either a 30‑day or 90‑day prescription with the TRINTELLIX Savings Card.‡
ǂOnly commercially insured patients ages 18 and older are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal-, state-, or government-funded healthcare programs, or by cash patients. Savings of up to $100 per 30-day or $300 per 90-day prescription, with maximum total savings of $1,300 over one year. Restrictions apply. See Savings Card for full Eligibility Requirements and Terms & Conditions.
IMPORTANT SAFETY INFORMATION about TRINTELLIX
Suicidal Thoughts & Actions
TRINTELLIX and other antidepressants increase the risk of suicidal thoughts and actions in people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. Call your doctor or get emergency help right away to report any of these, or if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.
Who should not take TRINTELLIX?
Do not start or take TRINTELLIX if you:
- are allergic to vortioxetine or any of the ingredients in TRINTELLIX
- are taking, or have stopped taking within the last 14 days, a medicine called a Monoamine Oxidase Inhibitor (MAOI), including the antibiotic linezolid or intravenous methylene blue
Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.
What should I tell my doctor before taking TRINTELLIX?
Before taking TRINTELLIX, tell your doctor:
- about all your medical and other health conditions
- if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX
- if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; lithium; tramadol, fentanyl, meperidine, methadone, or other opioids; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; diuretics; medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs); or medicines used to treat seizures or convulsions.
What are the possible side effects of TRINTELLIX?
TRINTELLIX may cause serious side effects, including:
- Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart-beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
- Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
- Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
- Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
- Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
- Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in their blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
- Sexual problems: Taking TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your doctor if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.
The most common side effects of TRINTELLIX include:
- nausea
- constipation
- vomiting
These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1‑800‑FDA‑1088.
What is TRINTELLIX (vortioxetine)?
TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.
There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at
For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.
IMPORTANT SAFETY INFORMATION about TRINTELLIX
Suicidal Thoughts & Actions
TRINTELLIX and other antidepressants increase the risk of suicidal thoughts and actions in people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions. Call your doctor or get emergency help right away to report any of these, or if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.
Who should not take TRINTELLIX?
Do not start or take TRINTELLIX if you:
- are allergic to vortioxetine or any of the ingredients in TRINTELLIX
- are taking, or have stopped taking within the last 14 days, a medicine called a Monoamine Oxidase Inhibitor (MAOI), including the antibiotic linezolid or intravenous methylene blue
Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.
What should I tell my doctor before taking TRINTELLIX?
Before taking TRINTELLIX, tell your doctor:
- about all your medical and other health conditions
- if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX
- if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; lithium; tramadol, fentanyl, meperidine, methadone, or other opioids; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; diuretics; medicines used to treat mood, anxiety, psychotic, or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs); or medicines used to treat seizures or convulsions.
What are the possible side effects of TRINTELLIX?
TRINTELLIX may cause serious side effects, including:
- Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart-beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
- Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
- Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
- Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
- Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
- Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in their blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
- Sexual problems: Taking TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your doctor if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.
The most common side effects of TRINTELLIX include:
- nausea
- constipation
- vomiting
These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1‑800‑FDA‑1088.
What is TRINTELLIX (vortioxetine)?
TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD). TRINTELLIX has not been shown to be safe and effective for use in children.
There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at
For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.
This site is intended for use by U.S. residents ages 18 and older only.
TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.
©2023 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).
1-877-TAKEDA-7 (1-877-825-3327).
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