90-day savings offer icon

You may pay as little as $10 for either a 30-day or 90-day prescription.*

Learn more

*Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. See Savings Card for Eligibility Requirements and Terms & Conditions.

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*Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. See Savings Card for Eligibility Requirements and Terms & Conditions.

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Personalized support. That helps.

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Savings and Support

Your personalized savings and support program

Enroll now to receive savings* and support at no cost to you.

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A support program built to partner with you as you start your treatment with TRINTELLIX (vortioxetine).

Customize your journey with support tools like:

Savings icon

Savings Card*

Pay as little as $10 for a 30- or 90-day prescription. Maximum savings of $100 on a 30-day or $300 on a 90-day script. Must meet eligibility requirements.

Mobile wallet

Mobile Wallet*

Download your Savings Card and add it to your mobile wallet for your next refill. Must meet eligibility requirements.

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Informative emails

Receive emails with tools to help empower you to have meaningful discussions with your doctor.

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Inspiring Texts and Refill Reminders When Needed

Uplifting messages and medication refill reminders sent to help you along the way.

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Chats with a tAccess Advisor

Call to receive information about the Savings Card and other support features (1-844-654-TRIN), 8:00 am – 8:00 pm EST M-F.

*All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. See Savings Card for Eligibility Requirements and Terms & Conditions.


Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. Must meet eligibility requirements.

What to do next, if you are eligible:

Need a Savings Card?

Sign Up For Savings

Have a Savings Card?

Activate Your Card

Lost your Savings Card?

Get Replacement Card
Help At Hand: Patient Assistance Within Reach

Need help affording your prescription?

Visit Takeda Help At Hand to learn more.

Mail-in rebate

Patient mail-in rebate forms and information on eligibility and how to complete and submit are available at www.patientrebateonline.com.
You may also request one by calling 1-866-279-0287.

Frequently Asked Questions

  • If eligible, you can register for the TRINTELLIX Savings Card here. If you are having trouble signing up online or have questions about eligibility requirements, you can also call 1-866-279-0287 to register.

  • The TRINTELLIX Savings Card offer cannot be used if you are a beneficiary of, or any part of your prescription is covered by: (1) any federal, state, or government-funded healthcare program (for example, Medicare, Medicaid, TRICARE), including a state pharmaceutical assistance program (the Federal Employees Health Benefits (FEHB) Program is not a government-funded healthcare program for purposes of this offer), (2) the Medicare Prescription Drug Program (Part D), or if you are currently in the coverage gap, or (3) insurance that is paying the entire cost of the prescription. Patient must be age 18 or older and have a valid prescription for TRINTELLIX. Cash patients are not eligible for the TRINTELLIX Savings Card.

  • If you’re an eligible patient signing up for a TRINTELLIX Savings Card online, you will receive your activated card online immediately. You can print the Savings Card and use it right away. If you’re having trouble activating your Savings Card online, please call 1-866-279-0287 to activate it.

    If you received a TRINTELLIX Savings Card from your healthcare professional in the brochure, you can activate it here, or call 1-866-279-0287. You will be asked for the ID number on the card.

    Once you’ve activated your TRINTELLIX Savings Card, take your prescription and your savings card to your pharmacist.*

    *Must meet eligibility requirements, and subject to a maximum savings amount of $100 per 30-day or $300 per 90-day prescription. See savings card for Eligibility Requirements and Terms & Conditions.

  • With the TRINTELLIX Savings Card, eligible patients can save on TRINTELLIX prescriptions and refills. You also get free access to the TRINTELLIX Support Program, tAccess, which provides support for people with MDD.

    See "Am I eligible for the TRINTELLIX Savings Card?" above.

  • The tAccess Support Program is personalized support for patients on TRINTELLIX therapy. The purpose of the program is to help patients stay on track with their treatment as directed by their healthcare professional.

    Patients who enroll in the tAccess Support Program can expect to receive:

    • Savings Card* - pay as little as $10 for a 30- or 90-day prescription. Maximum savings of $100 on a 30-day or $300 on a 90-day script. Must meet eligibility requirements.
    • Mobile Wallet* - download your Savings Card and add it to your mobile wallet for your next refill. Must meet eligibility requirements.
    • Informative Emails - Receive emails with tools to help empower you to have meaningful discussions with your doctor.
    • Inspiring Texts and Refill Reminders When Needed - Uplifting messages and medication refill reminders sent to help you along the way.
    • Chats with a tAccess Advisor - Call to receive information about the Savings Card and other support features (1-844-654-TRIN), 8:00 am – 8:00 pm EST M-F.

    *All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. See Savings Card for Eligibility Requirements and Terms & Conditions.

  • If the pharmacy has difficulty processing your card, have the pharmacy follow the steps on the back of your TRINTELLIX Savings Card. The pharmacy can also call 1-866-279-0287 for processing questions.

    If eligible and your pharmacist cannot process your card, or doesn’t accept your card and you’ve already paid for your prescription, please visit www.patientrebateonline.com and follow the instructions for savings. If you need further information, call 1-866-279-0287.

  • Patient mail-in rebate forms for eligible patients and information on how to complete and submit them are available at www.patientrebateonline.com. You may also request one by calling 1-866-279-0287.

  • For general information about TRINTELLIX Savings Cards, including information for getting a replacement card, call 1-866-279-0287.

  • Help At Hand is a patient assistance program that provides access to medicine for eligible patients with financial need. Visit Help At Hand to request an application. Restrictions apply.

Important Safety Information About TRINTELLIX

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Suicidal Thoughts and Actions and Antidepressant Drugs

Antidepressants may increase suicidal thoughts or actions in some children, teens or young adults within the first few months of treatment or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. People who have (or have a family history of) bipolar illness, or suicidal thoughts or actions may have a particularly high risk. Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts or feelings. Call your healthcare provider right away if symptoms such as anxiety, irritability, impulsivity, trouble sleeping, aggressive behavior or suicidal thoughts are new, worse or worry you. TRINTELLIX has not been evaluated for use in patients under 18.

Do not take TRINTELLIX if you:

  • Are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping TRINTELLIX; do not start TRINTELLIX if you stopped taking an MAOI in the last 14 days

TRINTELLIX may cause serious side effects including:

Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as TRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea.

Abnormal bleeding or bruising: TRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual.

Visual problems: May include eye pain, changes in vision, swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet; and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death.

Before starting TRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse.

TRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl.

Common side effects of TRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of TRINTELLIX.

Do not start or stop taking TRINTELLIX without talking to your healthcare provider first. Suddenly stopping TRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts of anger, dizziness or feeling lightheaded, or runny nose.

Talk to your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is TRINTELLIX?

TRINTELLIX is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD) in adults.

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.